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However, the effects of glomerular leakage and tubular injury, two common features of kidney diseases, on nanoparticle transport remain poorly understood. Herein, we investigated the blood retention, kidney accumulation, and renal clearance of Au\u2082\u2085(SG)\u2081\u2088 in a doxorubicin\u2010induced acute kidney injury (AKI) mouse model. By correlating its transport with proteinuria and urinary kidney injury molecule\u20101 (KIM\u20101), endogenous biomarkers of glomerular leakage and proximal tubular injury, respectively, we found that glomerular leakage, as indicated by a &gt;50\u2010fold increase in proteinuria, did not enhance its blood clearance. Instead, tubular injury significantly reduced glomerular filtration, resulting in elevated blood retention, increased kidney accumulation, and reduced renal clearance of Au\u2082\u2085(SG)\u2081\u2088. Moreover, Au\u2082\u2085(SG)\u2081\u2088 blood retention exhibited a very strong positive correlation with urinary KIM\u20101 (Pearson's coefficient\n                    <jats:italic>r<\/jats:italic>\n                    \u00a0=\u00a00.90), much stronger than KIM\u20101 correlations with conventional glomerular filtration blood markers such as serum creatinine. This suggests that Au\u2082\u2085(SG)\u2081\u2088 could serve as a sensitive exogenous blood marker of tubular injury, expanding the diagnostic potential of renal\u2010clearable nanoparticles in kidney diseases.\n                  <\/jats:p>","DOI":"10.1002\/anie.202509978","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T13:49:58Z","timestamp":1750945798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Blood Retention and Kidney Clearance of Renal\u2010Clearable Gold Nanoparticles Strongly Correlate with Renal Injury Biomarkers"],"prefix":"10.1002","volume":"64","author":[{"given":"Samira","family":"Ahrari","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Texas at Dallas Richardson  Texas 75080 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