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Moreover, these catalytic peptide assemblies are capable of templating melanin production. Guided by the structure activity relationships identified using the model systems we discovered that peptide assemblies formed by fragments of human carbonic anhydrase VII found in the brain also promote neurotransmitter degradation, supporting its role in neurodegenerative disease. Altogether, our results further support the role of metal\u2010promoted catalysis in neurodegenerative disease and will facilitate development of new catalyst nanomaterials capable of promoting oxidative transformation.<\/jats:p>","DOI":"10.1002\/anie.202510234","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:37:08Z","timestamp":1758886628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production"],"prefix":"10.1002","volume":"64","author":[{"given":"Inhye","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Baylor University  One Bear Place Waco TX 76798 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam R.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Baylor University  One Bear Place Waco TX 76798 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shams","family":"Aaghaz","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Baylor University  One Bear Place Waco TX 76798 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biophysics University of Texas Southwestern Medical Center  6001 Forest Park Road Dallas TX 75390 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Yee Joyce","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Biophysics University of Texas Southwestern Medical Center  6001 Forest Park Road Dallas TX 75390 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8144-783X","authenticated-orcid":false,"given":"Ivan V.","family":"Korendovych","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Baylor University  One Bear Place Waco TX 76798 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1998.tb03880.x"},{"key":"e_1_2_5_2_1","volume":"2","author":"Mayeux R.","year":"2012","journal-title":"CSH Perspect. 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