{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:21:51Z","timestamp":1788304911275,"version":"build-2803163510"},"reference-count":89,"publisher":"Wiley","issue":"34","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA1506400"],"award-info":[{"award-number":["2023YFA1506400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22361132533"],"award-info":[{"award-number":["22361132533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22471157"],"award-info":[{"award-number":["22471157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The development of asymmetric hydrogenation catalysts based on Earth\u2010abundant metals presents a sustainable alternative to efficient but resource\u2010limited rare\u2010metal systems. However, these catalysts often suffer from low catalytic activity. In this study, through a combination of density functional theory (DFT) calculations and kinetic experiments, we uncovered a positive correlation between catalyst\u2010substrate weak noncovalent interactions and catalytic efficiency in the enantioselective nickel\u2010catalyzed hydrogenation of \u03b1\u2010alkylidene succinimides with different\n                    <jats:italic>N<\/jats:italic>\n                    \u2010protecting groups. The\n                    <jats:italic>tert<\/jats:italic>\n                    \u2010butyl (\n                    <jats:italic>t<\/jats:italic>\n                    Bu) substituent emerged as the optimal choice, significantly enhancing reactivity. This approach enabled the hydrogenation of a wide range of substrates with excellent yields (up to 99%) and enantioselectivities (up to 99%\u00a0ee), achieving a substrate\/catalyst (S\/C) ratio of 4000\u2014twice the efficiency of rare\u2010metal catalysts (S\/C\u00a0\u2264\u00a02000) for similar transformations. Energy decomposition analysis (EDA) of the enantiomers revealed that the high stereoselectivity is promoted by stabilizing weak noncovalent interactions in the\n                    <jats:italic>R<\/jats:italic>\n                    \u2010configured transition state.\n                  <\/jats:p>","DOI":"10.1002\/anie.202510401","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T08:49:29Z","timestamp":1750409369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enantioselective Nickel\u2010Catalyzed Hydrogenation of \u03b1\u2010Alkylidene Succinimides Enabled by Weak Noncovalent Interactions"],"prefix":"10.1002","volume":"64","author":[{"given":"Xinhong","family":"Cai","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University Frontier Science Center for Transformative Molecules State Key Laboratory of Synergistic Chem\u2010Bio Synthesis School of Chemistry and Chemical Engineering Shanghai Jiao Tong University  800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yicong","family":"Luo","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University Frontier Science Center for Transformative Molecules State Key Laboratory of Synergistic Chem\u2010Bio Synthesis School of Chemistry and Chemical Engineering Shanghai Jiao Tong University  800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University Frontier Science Center for Transformative Molecules State Key Laboratory of Synergistic Chem\u2010Bio Synthesis School of Chemistry and Chemical Engineering Shanghai Jiao Tong University  800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-4195","authenticated-orcid":false,"given":"Wanbin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Zhengzhou Industrial Technology Research Institute of Shanghai Jiao Tong University Frontier Science Center for Transformative Molecules State Key Laboratory of Synergistic Chem\u2010Bio Synthesis School of Chemistry and Chemical Engineering Shanghai Jiao Tong University  800 Dongchuan Road Shanghai 200240 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00127a034"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600800818"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-894X(95)00254-Q"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18055669"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2800"},{"key":"e_1_2_7_6_1","unstructured":"J. Y.Nagasawa I.Botrous A. G.Lai A. R.Hudson N. D.Simth S. P.Govek WO 2023\/043836 A1 2023."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.9651"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)89217-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2005.12.126"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc33914e"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2020.131827"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200501305"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja061430d"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0671013"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja074824t"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr078371m"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja900582a"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200907033"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5007182"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201209126"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201309677"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b01615"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-35124-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202213600"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700113g"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr100218m"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs15312b"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200328h"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35333D"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2CS35410A"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00564"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202000605"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00075"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00496"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.2c00764"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS00329A"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4QO00227J"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00875"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202016771"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0SC07099H"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202108503"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04983"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202303600"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202319662"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202415171"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c06618"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00134"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc201502032"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00043"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800053"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00404"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc201912025"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00082E"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc202208003"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.6023\/A23040140"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315773"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202400352"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2023.05.006"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12597"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07581-z"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202504159"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201902576"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19807-5"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00971-8"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916534"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202214990"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49801-0"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c10623"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.15227\/orgsyn.102.0236"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909928"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202306380"},{"key":"e_1_2_7_72_1","author":"Guan J.","year":"2024","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3QO00332A"},{"key":"e_1_2_7_74_1","author":"Chen J.","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07957"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.0c03723"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c00839"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/a804198i"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.6023\/cjoc201502017"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202110286"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09266"},{"key":"e_1_2_7_82_1","unstructured":"Deposition number 2348850 (for2r) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe Access Structures service."},{"key":"e_1_2_7_83_1","unstructured":"B.Severson D.Chung C.Jonsson E.White L.Rasmussen C.Maddox S.Ananthan A.Pathak J.Maddry WO Patent 2011\/097 607 2011."},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.03.075"},{"key":"e_1_2_7_85_1","unstructured":"I.Ebashi T.Takigawa M.Inoue U.S. Patent 1994 5 336\u2013782 ."},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01033"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00658"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01561"},{"key":"e_1_2_7_89_1","unstructured":"Y.Shi M.Wu W.Tan Y.Wu Q.Huang S.Zhi J.Tang R.Jiang X.Tie B.Xu CN Patent 117 551 018 2024."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202510401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202510401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202510401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T18:14:39Z","timestamp":1775844879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202510401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,29]]},"references-count":89,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2025,8,18]]}},"alternative-id":["10.1002\/anie.202510401"],"URL":"https:\/\/doi.org\/10.1002\/anie.202510401","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,29]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202510401"}}