{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:36:21Z","timestamp":1787168181907,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"33","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["3085\/21"],"award-info":[{"award-number":["3085\/21"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,8,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The extent of helicity in nonplanar polyaromatic materials affects their electronic, optical and chiroptical properties. However, controlling helicity in different systems typically requires different multistep synthetic approaches for each target compound, often with significant complexity, thereby limiting its applicability. Here, we introduce a helical synthon, isobenzofuranophane, with either a short or long tether, which enables late\u2010stage helicity induction and control in aromatic frameworks. We demonstrate the applicability of this synthon by reacting it with a [5]helicene aryne precursor, where both the handedness and helicene pitch are remotely\u2010controlled by the tether length, directly affecting the (chiro)optical properties of the helicene. The X\u2010ray structures support these findings with up to 35\u00b0 torsion for a single benzene ring, demonstrating the potential of isobenzofuranophane to induce significant curvature to polyaromatic molecules.<\/jats:p>","DOI":"10.1002\/anie.202510423","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T15:39:17Z","timestamp":1749656357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Controlling the Helicity and Handedness of Polyaromatics with Isobenzofuranophane"],"prefix":"10.1002","volume":"64","author":[{"given":"Abhijeet R.","family":"Agrawal","sequence":"first","affiliation":[{"name":"Institute of Chemistry and the Center for Nanoscience and Nanotechnology The Hebrew University of Jerusalem  Edmond J. 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Safra Campus Jerusalem 9190401 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Shalev","sequence":"additional","affiliation":[{"name":"The Metabolic Profiling Unit The Core Research Facility The Faculty of Medicine The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and the Center for Nanoscience and Nanotechnology The Hebrew University of Jerusalem  Edmond J. Safra Campus Jerusalem 9190401 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7037-0563","authenticated-orcid":false,"given":"Ori","family":"Gidron","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and the Center for Nanoscience and Nanotechnology The Hebrew University of Jerusalem  Edmond J. 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