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Although advances like high\u2010throughput additive screening and commercial catalyst\/ligand libraries improve prediction in specific systems, a general strategy for vinyl halide cross\u2010coupling across diverse bond\u2010forming reactions remains elusive. Herein, we report a general and highly predictable method for vinyl halide cross\u2010coupling under photoredox conditions, employing two complementary catalytic systems. In the first, the organic photocatalyst 4CzIPN enables efficient coupling with nucleophiles such as thiols, selenols, sulfinate salts, activated alkenes, phosphorus (III), and boron compounds, affording C(sp\n                    <jats:sup>2<\/jats:sup>\n                    )\u2500S, \u2500Se, \u2500C, \u2500P, and \u2500B bonds in high yields. In the second, a dual nickelphotoredox catalytic system facilitates coupling with less reactive nucleophiles, including phosphorus (V), nitrogen, and oxygen. This approach enables seven distinct bond\u2010forming reactions, offering broad electrophile and nucleophile scope, high functional group tolerance, and applicability to the late\u2010stage functionalization of complex biomolecules. The simple and consistent conditions enable one\u2010pot, two\u2010step bifunctional transformations by sequentially activating distinct chemical bonds involving nucleophiles and electrophiles.\n                  <\/jats:p>","DOI":"10.1002\/anie.202510715","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T06:15:45Z","timestamp":1756534545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Generalizing Vinyl Halide Cross\u2010Coupling Reactions with Photoredox and Photoredox\/Nickel Dual Catalysis"],"prefix":"10.1002","volume":"64","author":[{"given":"Kousik","family":"Das","sequence":"first","affiliation":[{"name":"Fakult\u00e4t f\u00fcr Chemie und Pharmazie Universit\u00e4t Regensburg 93053 Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayan","family":"Saha","sequence":"additional","affiliation":[{"name":"Fakult\u00e4t f\u00fcr Chemie und 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