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However, most such probes are usually responsive to single pathological factor and visible\u2010near\u2010infrared\u2010I light upon activation, which restricts the theranostic specificity and tissue penetration depth, respectively. Herein, we develop a nitric oxide (NO) and acidity dual\u2010stimuli responsive semiconducting polymer nanoprobe for activatable near\u2010infrared\u2010II (NIR\u2010II) photoacoustic imaging (PAI) and photothermal therapy (PTT). Specifically, a weak electron acceptor (benzo[<jats:italic>c<\/jats:italic>][1,2,5]thiadiazole\u20105,6\u2010diamine, BT2NH<jats:sub>2<\/jats:sub>) has been conjugated with diketopyrrolopyrrole to construct the pathological factor\u2010sensitive molecular probe. Upon the coactivation of NO and acidity, the BT2NH<jats:sub>2<\/jats:sub> is oxidized to generate a strong electron acceptor (5<jats:italic>H<\/jats:italic>\u2010[1,2,3]triazolo[4,5\u2010<jats:italic>f<\/jats:italic>]\u20102,1,3\u2010benzothiadiazole, BT3N), leading to the absorption enhancement in the NIR\u2010II region. In vitro and in vivo studies indicate the successful activation of the probe toward activated macrophages, various cancer cells, drug\u2010induced liver injury, and breast cancer to output enhanced NIR\u2010II photoacoustic and photothermal signals, permitting highly specific PAI and PTT with reduced background interference and minimal therapeutic side effects. By virtue of the improved specificity and superior penetration depth, the dual\u2010stimuli responsive NIR\u2010II probe has broad prospects for precise visualization and intervention toward NO and acid\u2010associated pathological and physiological events from deep tissues.<\/jats:p>","DOI":"10.1002\/anie.202511084","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:15:24Z","timestamp":1756451724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["\u201cDual\u2010Key\u201d\u2010Controlled Activatable Semiconducting Polymer Nanoprobe for Highly Precision Phototheranostics Under NIR\u2010II Light Excitation"],"prefix":"10.1002","volume":"64","author":[{"given":"Guangzhao","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing University of Posts &amp; Telecommunications  9 Wenyuan Road Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-4936","authenticated-orcid":false,"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing University of Posts &amp; Telecommunications  9 Wenyuan Road Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotong","family":"Yin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing University of Posts &amp; Telecommunications  9 Wenyuan Road Nanjing 210023 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing 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