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A new bioinspired organocatalyst, 1,8\u2010diazafluoren\u20109\u2010one (DFO), has been discovered, which exhibits impressive characteristics, including simple structure, high robustness, and strong electrophilicity, enabling it to effectively mimic the function of copper amine oxidases. Oxidative deamination of \u03b1\u2010amino amides presents an attractive approach to access \u03b1\u2010keto amides; however, it is difficult to achieve due to their electron\u2010withdrawing nature and steric effect. The diazafluorenone displays high catalytic activity in this transformation, producing various biologically significant \u03b1\u2010keto amides in moderate to excellent yields. Furthermore, the diazafluorenone catalyst is able to promote direct oxidation of benzylamines into aromatic aldehydes, instead of the generally formed product\u2010reactant imines, which leads to no greater than 50% yields of the desired aldehydes. 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