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Hydrogel freezing involves both ice nucleation and ice growth; however, simultaneously inhibiting these two processes remains a significant challenge. In nature, freeze\u2010tolerant organisms do not rely on completely preventing ice formation to survive freezing conditions. Instead, they utilize bacterial membrane\u2010anchored ice nucleating protein (BMIP) to promote ice nucleation and ice binding protein (IBP) to regulate ice growth, thereby achieving freeze protection through precise ice management. Inspired by this biological strategy of \u201cselective nucleation of small ice crystals with restricted growth,\u201d we developed anti\u2010freezing hydrogels by incorporating both BMIP and IBP. The anti\u2010freezing hydrogels exhibit enhanced mechanical and electrical performance at low temperatures, with a non\u2010freezing matrix stable down to \u221230\u00b0C and excellent structural integrity over multiple freeze\u2010thaw cycles. When employed as a functional component of a robotic hand designed for low\u2010temperature operation and integrated with machine learning algorithms, the anti\u2010freezing hydrogels enable precise recognition of object stiffness and size under ultra\u2010low temperature conditions. This bioinspired approach provides a promising strategy for the development of next\u2010generation anti\u2010freezing hydrogels capable of supporting stable human\u2010robot\u2010environment interactions in harsh, low\u2010temperature environments.<\/jats:p>","DOI":"10.1002\/anie.202512142","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:53:50Z","timestamp":1755500030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bioinspired Anti\u2010Freezing Hydrogel With Localized Ice Regulation for Subzero Soft Robotics"],"prefix":"10.1002","volume":"64","author":[{"given":"Hongzhong","family":"Du","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Beijing Institute of Technology  Beijing 100081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Chen","sequence":"additional","affiliation":[{"name":"School 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