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Here, we report the synthesis of a heteromultivalent nanogel system against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    (\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    ). These nanogels are based on biocompatible polyglycerols and functionalized with sugar ligands fucose (Fuc) or galactose (Gal) for\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    targeting. With a further modification of these nanogels with BMAP\u201018 short chain peptides (GRFKRFRKKFKKLFKKLS), we have achieved\u00a0&gt;\u00a099.99% inactivation of planktonic and\u00a0&gt;\u00a099.9% inactivation of biofilm\u2010coated\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    within 12 h of treatment. Additionally, the system demonstrates broad\u2010spectrum antimicrobial potential, effectively inhibiting\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (\n                    <jats:italic>E. coli<\/jats:italic>\n                    ) and Methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA). This modular design offers a promising strategy for the development of next\u2010generation antimicrobial therapies targeting biofilm\u2010associated infections and MDR bacteria.\n                  <\/jats:p>","DOI":"10.1002\/anie.202513121","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T08:07:53Z","timestamp":1762848473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heteromultivalent Nanogels as Highly Potent Inhibitors of\n                    <i>Pseudomonas Aeruginosa<\/i>"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6570-245X","authenticated-orcid":false,"given":"Yuhang","family":"Jiang","sequence":"first","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7963-1187","authenticated-orcid":false,"given":"Chuanxiong","family":"Nie","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7777-1984","authenticated-orcid":false,"given":"Vinod","family":"Khatri","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"},{"name":"Department of Chemistry TDL Govt. College for Women  Murthal Sonipat 131027 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Puccio","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Long","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Dimde","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-162X","authenticated-orcid":false,"given":"Rainer","family":"Haag","sequence":"additional","affiliation":[{"name":"Institute for Chemistry and Biochemistry Freie Universit\u00e4t Berlin  Takustra\u00dfe 3 14195 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-4937","authenticated-orcid":false,"given":"Sumati","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science and Engineering Swansea University  Swansea SA2 8PP UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,11]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2019.04.001"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00039"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.2005.25.10.1353"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27701\u20100"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201010201\u20104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000094551.88143.f8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402831"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033920\u20107"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2852"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b11133"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215535"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.116072"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph6121543"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(20)30327\u20103"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00624"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201069995\u20109"},{"key":"e_1_2_6_18_1","first-page":"3919","volume":"11","author":"Lei J.","year":"2019","journal-title":"Am. 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