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Recent work has shown that, by dissolving the substrate in deep eutectic solvents (DES), these processes can be carried out on the benchtop, in air at room temperature. Surprisingly, the organometallic reagent, added to the DES from an organic solution, works in these conditions and gives better yields than in the standard setup. Here, we investigated acetophenone in a (1:2) choline chloride:glycerol (ChCl:Gly) DES solution by experimental liquid diffraction, neutron reflectometry, NMR, interfacial tension measurements, and by computational modelling. Our data show that this DES is a poor solvent for the ketone and promotes its accumulation at the surface of the liquid or its escape into the organic solvent. Molecular dynamics simulations of Grignard reagent\n                    <jats:italic>i<\/jats:italic>\n                    \u2010PrMgCl in the (ChCl:Gly)\/tetrahydrofuran biphasic system indicate also preference for its localisation at the interface. These results pinpoint why this combination of solvents promote the reaction, require stirring, and accounts for the lack of rapid decomposition of the organometallic\u00a0reagents.\n                  <\/jats:p>","DOI":"10.1002\/anie.202513649","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:27:30Z","timestamp":1756794450000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Are Grignard Reactions in Deep Eutectic Solvents Interface\u2010Driven?"],"prefix":"10.1002","volume":"64","author":[{"given":"Iva","family":"Manasi","sequence":"first","affiliation":[{"name":"Department of Physics University of Bristol, Tyndall Avenue Bristol BS8 1TL United Kingdom"},{"name":"Department of Chemistry University of Bath Claverton Down Bath BA2 7AX United 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