{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:48:59Z","timestamp":1791650939190,"version":"4.3.4"},"reference-count":68,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005969","name":"Universit\u00e0 di Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,9,15]]},"abstract":"Abstract<\/jats:title>\n \n We present a straightforward and versatile synthetic route to Fe\n 6<\/jats:sub>\n C carbide carbonyl clusters containing organosulfur ligands, including the chiral amino acid\n L<\/jats:italic>\n \u2010 and\n D<\/jats:italic>\n \u2010cysteine. Reaction of the reduced cluster [NEt\n 4<\/jats:sub>\n ]\n 4<\/jats:sub>\n [Fe\n 6<\/jats:sub>\n C(CO)\n 15<\/jats:sub>\n ] (\n 1<\/jats:bold>\n ) with thiols (RSH) or disulfides (RSSR) affords novel functionalized hexa\u2010iron carbide clusters [NEt\n 4<\/jats:sub>\n ]\n 3<\/jats:sub>\n [Fe\n 6<\/jats:sub>\n C(CO)\n 14<\/jats:sub>\n (SR)] (R\u00a0=\u00a0CH\n 3<\/jats:sub>\n ,\n 2<\/jats:bold>\n ; C\n 6<\/jats:sub>\n H\n 5<\/jats:sub>\n ,\n 3<\/jats:bold>\n ;\n p<\/jats:italic>\n \u2010C\n 6<\/jats:sub>\n H\n 4<\/jats:sub>\n CH\n 3<\/jats:sub>\n ,\n 4<\/jats:bold>\n ;\n L<\/jats:italic>\n \u2010cysteine,\n \n L<\/jats:italic>\n <\/jats:bold>\n \u2010\n 5<\/jats:bold>\n ;\n D<\/jats:italic>\n \u2010cysteine,\n \n D<\/jats:italic>\n <\/jats:bold>\n \u2010\n 5<\/jats:bold>\n ). Compounds\n 2\u20135<\/jats:bold>\n have been characterized by Fourier transform infrared (FT\u2010IR),\n 1<\/jats:sup>\n H and\n 13<\/jats:sup>\n C{\n 1<\/jats:sup>\n H} nuclear magnetic resonance (NMR) spectroscopy, and the molecular structures of\n 2\u20134<\/jats:bold>\n have been determined by single\u2010crystal X\u2010ray diffraction (SC\u2010XRD). The chirality of the\n \n L<\/jats:italic>\n \u20105\n <\/jats:bold>\n and\n \n D<\/jats:italic>\n \u20105\n <\/jats:bold>\n enantiomers has been investigated by vibrational circular dichroism (VCD), and this represents the first VCD study of chiral metal carbonyl clusters. Combined analyses of VCD and calculated density functional theory (DFT) spectra clearly point out the occurrence of chirality transfer from the chiral organosulfur ligand to the CO ligands, as indicated by the presence of VCD bands in the \u03bd\n CO<\/jats:sub>\n region of both\n \n L<\/jats:italic>\n \u20105\n <\/jats:bold>\n and\n \n D<\/jats:italic>\n \u20105\n <\/jats:bold>\n . This unprecedented transfer of chirality among different ligands arises from close interactions between the CH\n 2<\/jats:sub>\n and CH hydrogens of coordinated cysteine and the CO shell of the clusters.\n <\/jats:p>","DOI":"10.1002\/anie.202513702","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T10:54:58Z","timestamp":1754045698000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single\u2010Step Insertion of Organic Sulfur Into a Fe\n 6<\/sub>\n C Carbide Carbonyl Cluster, Including the Natural Amino Acid\n L<\/i>\n \u2010Cysteine: Vibrational Circular Dichroism and Chirality Transfer"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5079-2136","authenticated-orcid":false,"given":"Francesca","family":"Forti","sequence":"first","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. Gobetti 85\u201040129 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5322-5949","authenticated-orcid":false,"given":"Andrea","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. Gobetti 85\u201040129 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2595-2078","authenticated-orcid":false,"given":"Cristiana","family":"Cesari","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. Gobetti 85\u201040129 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4317-6543","authenticated-orcid":false,"given":"Cristina","family":"Femoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. Gobetti 85\u201040129 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-7999","authenticated-orcid":false,"given":"Maria Carmela","family":"Iapalucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. Gobetti 85\u201040129 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-5265","authenticated-orcid":false,"given":"Michele","family":"Mancinelli","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. Gobetti 85\u201040129 Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-0518","authenticated-orcid":false,"given":"Stefano","family":"Zacchini","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Industriale \u201cToso Montanari\u201d Universit\u00e0 di Bologna Via P. 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