{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:32:06Z","timestamp":1789144326518,"version":"build-2803163510"},"reference-count":87,"publisher":"Wiley","issue":"42","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2022305"],"award-info":[{"award-number":["2022305"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92461302"],"award-info":[{"award-number":["92461302"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22071244"],"award-info":[{"award-number":["22071244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275191"],"award-info":[{"award-number":["22275191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2025,10,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multicomponent reactions (MCRs), a powerful strategy for generating desired products by employing more than two starting materials in one\u2010pot reactions, have been determined to be a superior synthetic strategy to achieve structural complexity and functional diversity. However, the use of MCRs in fabricating the multicomponent covalent organic cages (MCOCs) is still in its infancy. Here we report coronavirus\u2010shaped MCOCs, formed by MCR involving a Schiff\u2010base reaction (C\u2550N bonds), coupled with the formation of dative B\u2190N and B\u2500O bonds. Specifically, reaction of bowl\u2010shaped tetraformylcalix[4]resorcinarene, linear heteroditopic amino\u2010substituted phenylboronic acid, and spike alcohol synthons can afford [6+24+24] MCOCs with a large octahedral cavity, 8 triangle windows, 12 rhombic windows, and 24 functional alcohols, as determined by single crystal X\u2010ray crystallographic analysis. Notably, the number of components for the MCOCs reaches up to 54, making them the highest in covalent organic cages. Such MCR self\u2010assembly can also afford MCOCs other sizes and topologies just using amino\u2010substituted phenylboronic acid synthons with different lengths and angles. Interestingly, the MCOCs can be functionalized by alcohols with different substituent groups via both one\u2010pot reaction and post\u2010synthetic modification methods for desired properties. This work emphasizes the utilization of MCRs in constructing functional high\u2010component organic cages with desired properties.<\/jats:p>","DOI":"10.1002\/anie.202514219","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T12:08:02Z","timestamp":1755518882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Multicomponent Assembly of High\u2010Component Covalent Organic Cages"],"prefix":"10.1002","volume":"64","author":[{"given":"Donghai","family":"Shao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 China"},{"name":"College of Chemistry Fuzhou University  Fuzhou 350116 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 China"},{"name":"University of the Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kongzhao","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 China"},{"name":"University of the Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-072X","authenticated-orcid":false,"given":"Daqiang","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences  Fuzhou Fujian 350002 China"},{"name":"University of the Chinese Academy of Sciences  Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1994.1473"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6320"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00303"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00582"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00503"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20771"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja302142c"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","unstructured":"K.Wu T. K.Ronson P.Su Z.Chen L.Goh A. W.Heard X.Li F.Klautzsch C. A.Schalley M. J. N. S.Vinkovi\u0107 2023 2 789.","DOI":"10.1038\/s44160-023-00276-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-08266-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c11071"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00761A"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00667"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.53"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01142H"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","unstructured":"D.Zhang T. K.Ronson Y.\u2010Q.Zou J. R. J. N. R. C.Nitschke 2021 5 168.","DOI":"10.1038\/s41570-020-00246-1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00803"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00038H"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/38985"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202013105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01488"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2024.11.009"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00861A"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00198"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00811"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)88299-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202318362"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c12002"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09508"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41056-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c14213"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00475"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c02040"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2023.109201"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16508"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2021.09.016"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c04761"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","unstructured":"J.Yang R.Shi L.\u2010L.Mao H.Xiao Y.Zeng G.Liao Y.Weng X.\u2010B.Li J.Zhao Y.Zhao T.Zhang C.\u2010H.Tung L.\u2010Z.Wu H.Cong 2024 6 1920.","DOI":"10.31635\/ccschem.023.202303393"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202306722"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2020.10.002"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44160-024-00531-7"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408494"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46071-8"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b02716"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900163"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201813773"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31785-4"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-019-0399-2"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c10104"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjsc.2024.100312"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.023.202302903"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CC05091B"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR00703E"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.25377"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201611260"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sc00320h"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.3c00310"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201909237"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202007571"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200705272"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrp.2023.101285"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol100407f"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2007.07.035"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja060720r"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201610801"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00744"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr800296p"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00153B"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00006a043"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07367"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.31635\/ccschem.024.202303625"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24042-7"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11426-024-2162-5"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9084918"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC04531H"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202423226"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c00658"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202313379"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2022.10.023"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-024-01580-3"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c04397"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444993011333"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202102982"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405320"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46809-4"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-021-01168-z"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201308924"},{"key":"e_1_2_7_87_1","unstructured":"Deposition Numbers 2407583 (forMCOC\u20101) 2407584 (forMCOC\u20101\u2010EGO) 2407585 (forMCOC\u20102) 2407586 (forMCOC\u20103) 2407587 (forMCOC\u20103\u2010PrO) 2407588 (forMCOC\u20103\u2010TfO) 2407589 (forMCOC\u20104) contain the supplementary crystallographic data for this paper. These data are provided free of charge by the joint Cambridge Crystallographic Data Centre and Fachinformationszentrum Karlsruhe (http:\/\/www.ccdc.cam.ac.uk\/structures) Access Structures service."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202514219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202514219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202514219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T14:06:24Z","timestamp":1784297184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202514219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":87,"journal-issue":{"issue":"42","published-print":{"date-parts":[[2025,10,13]]}},"alternative-id":["10.1002\/anie.202514219"],"URL":"https:\/\/doi.org\/10.1002\/anie.202514219","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,18]]},"assertion":[{"value":"2025-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202514219"}}