{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:47:40Z","timestamp":1792259260856,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Anti\u2010inflammatory colchicine therapy has emerged as a new era for atherosclerotic cardiovascular diseases. However, the therapeutic benefit of colchicine has not been clearly defined. Herein, we present a double coordination\u2010driven approach to fabricate a stable metal\u2010organic nano\u2010assembly of colchicine (COL\u2010TA\u2010Zn) by uniting the tropolone ring of colchicine (COL), phenolic groups of tannic acid (TA), and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    ions. This design leverages the antioxidant and anti\u2010inflammatory properties of COL and TA to create a nanoscale platform capable of scavenging radicals and modulating inflammatory pathways. Through robust Zn\n                    <jats:sup>2+<\/jats:sup>\n                    coordination, the resulting COL\u2010TA\u2010Zn nanocomplexes exhibit enhanced stability under physiological conditions, ensuring efficient delivery and sustained bioactivity. In vitro assays confirm suppression of foam cell formation and multiple inflammatory mediators, suggesting significant potential for managing atherosclerosis by targeting both oxidative stress and inflammation. Intravenous administration of COL\u2010TA\u2010Zn in\n                    <jats:italic>Apoe<\/jats:italic>\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>\/<\/jats:sup>\n                    <jats:sup>\u2212<\/jats:sup>\n                    mice significantly reduces atherosclerotic plaque area, MMP\u20109, TNF\u2010\u03b1, and reactive oxygen species (ROS) levels, thereby illustrating its superior anti\u2010atherosclerotic efficacy compared to COL alone. These findings highlight the promise of the dual coordination\u2010driven nanoplatform in cardiovascular disease treatment.\n                  <\/jats:p>","DOI":"10.1002\/anie.202514547","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:38:47Z","timestamp":1767854327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Self\u2010Assembled Metal\u2010Polyphenol Colchicine Nanoparticles Targeting Oxidative Stress and Inflammation for Treatment of Atherosclerosis"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-3293","authenticated-orcid":false,"given":"Franco","family":"Centurion","sequence":"first","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW) Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9629-2989","authenticated-orcid":false,"given":"Xiuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW) Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound of Shanghai East Hospital Tongji University School of Medicine  Shanghai 200120 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun","family":"Kundi","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW) Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyank","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW) Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-7267","authenticated-orcid":false,"given":"Meihua","family":"Yu","sequence":"additional","affiliation":[{"name":"Materdicine Lab, School of Life Sciences Shanghai University  Shanghai 200444 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-8665","authenticated-orcid":false,"given":"Dominique","family":"Appadoo","sequence":"additional","affiliation":[{"name":"THz Beamline Australian Synchrotron  Clayton Victoria 3168 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-1265","authenticated-orcid":false,"given":"Aditya","family":"Rawal","sequence":"additional","affiliation":[{"name":"Mark Wainwright Analytical Centre University of New South Wales (UNSW) Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3042-8302","authenticated-orcid":false,"given":"Ashish","family":"Misra","sequence":"additional","affiliation":[{"name":"Heart Research Institute; Faculty of Medicine and Health, The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patel","sequence":"additional","affiliation":[{"name":"Heart Research Institute; Faculty of Medicine and Health, The University of Sydney Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8206-3325","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Materdicine Lab, School of Life Sciences Shanghai University  Shanghai 200444 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-6596","authenticated-orcid":false,"given":"Zi","family":"Gu","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW) Sydney New South Wales 2052 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,7]]},"reference":[{"key":"e_1_2_8_1_1","first-page":"56","volume":"5","author":"Libby P.","year":"2019","journal-title":"Nat. Rev. Dis."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.120"},{"key":"e_1_2_8_3_1","first-page":"274","volume":"24","author":"Piironen M.","year":"2017","journal-title":"Eur. J. 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