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The C19 oxidized\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010decalin core was constructed via a tail\u2010to\u2010head cyclization of an epoxide ene\u2010yne compound containing an internal oxygenated methyl\u2010bearing alkene. This process involved a titanium(III) catalyzed epoxide ring\u2010opening\/ene\u2010yne cyclization. The furan fragment was assembled through a metallaphotoredox\u2010enabled deoxygenative coupling of an alcohol precursor. A SmI\n                    <jats:sub>2<\/jats:sub>\n                    \u2010mediated elimination of a pre\u2010installed acetal established the 2,3\u2010dihydrofuran motif.\n                  <\/jats:p>","DOI":"10.1002\/anie.202515206","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T04:25:34Z","timestamp":1759811134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Total Synthesis of Clerodin"],"prefix":"10.1002","volume":"64","author":[{"given":"Qishuang","family":"Yin","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University  222 South Tianshui Road Lanzhou Gansu Province 730000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College 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