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However, the key parameters governing the polarized luminescence process remain difficult to predict and rationalize since the phosphorescence emission is rarely obtained in solution, hampering any structure\u2010relationship studies. To address this challenge, we report here the synthesis and chiroptical properties of a new family of metal\u2010free phosphorescent emitters based on phthalimide derivatives. Breaking symmetry of the phthalimide units and using intra\u2010 and intermolecular hydrogen bonding enable the obtention of circularly polarized (CP) RTP in solution with\n                    <jats:italic>g<\/jats:italic>\n                    <jats:sub>lum<\/jats:sub>\n                    of up to 5\u00a0\u00d7\u00a010\n                    <jats:sup>\u22123<\/jats:sup>\n                    . Interestingly, our investigations demonstrate the intricate role of hydrogen bonding interactions in modulating triplet state generation through the mixing of singlet and triplet states of different nature, i.e., n\u2010\u03c0* and \u03c0\u2013\u03c0*, in the excited state, which is a crucial parameter for achieving intense CP\u2010RTP. These results bring additional molecular design guidelines to reach CP\u2010RTP in solution and additionally offer new insights into the subtle relationships between excited states of different spin multiplicity to reach higher CP phosphorescence intensity.\n                  <\/jats:p>","DOI":"10.1002\/anie.202515218","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:28:12Z","timestamp":1760002092000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Symmetry Breaking and Hydrogen Bonding in Phthalimide Compounds Enable Efficient Room\u2010Temperature Circularly Polarized Phosphorescence in Solution"],"prefix":"10.1002","volume":"64","author":[{"given":"Catherine","family":"Demangeat","sequence":"first","affiliation":[{"name":"Univ Rennes, CNRS, ISCR \u2013 UMR 6226  Rennes F\u201035000 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France"},{"name":"Institut Universitaire de France (IUF)  Paris F\u201075005 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7847-2911","authenticated-orcid":false,"given":"Ludovic","family":"Favereau","sequence":"additional","affiliation":[{"name":"Univ Rennes, CNRS, ISCR \u2013 UMR 6226  Rennes F\u201035000 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TC03030B"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60449G"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0066613"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201705945"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00060"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chempr.2016.08.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar50001a002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp909388y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00092D"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mser.2009.09.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3tc00878a"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.2c08691"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201807268"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201913393"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.1c01552"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcc.0c07864"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/adom.202300289"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202011770"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC05908H"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc44809f"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.4c03482"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TC04176A"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC02841D"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b00789"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202301369"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202203800"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010017\u20100045"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010023\u201000543\u20103"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23551"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202417906"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.00555"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201501178"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41566-024-01538-4"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QM00409A"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202101538"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202501330"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028070\u20109"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202401506"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.0c01816"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-636X(2000)12:4<263::AID-CHIR12>3.0.CO;2-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja982131u"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104020(96)00795\u20108"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1039\/FT9949000411"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/b610051a"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200802196"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.199619491"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/1010\u20106030(88)80006\u20106"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201800198"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00680J"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202010281"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009\u20102614(89)85055\u20109"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC00395A"}],"container-title":["Angewandte 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