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However, the synthesis of\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010labeled molecules suffers from the complex procedure of de novo synthesis and harsh conditions. Here, we propose an electrochemical strategy to synthesize\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010labeled oximes (\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010oximes) from\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010labeled nitrites (\n                    <jats:sup>15<\/jats:sup>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    ) and aldehydes\/ketones. Matching the adsorption and activation of H\n                    <jats:sub>2<\/jats:sub>\n                    O and\n                    <jats:sup>15<\/jats:sup>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    and inhibiting\n                    <jats:sup>15<\/jats:sup>\n                    NH\n                    <jats:sub>2<\/jats:sub>\n                    OH overhydrogenation are the keys to realizing efficient ampere\u2010level electrosynthesis of\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010labeled oximes. A bismuth\u2212molybdenum (BiMo) alloy catalyst is subsequently designed, in which Bi acts as the\n                    <jats:sup>15<\/jats:sup>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    activation site, whereas Mo serves as the H\n                    <jats:sub>2<\/jats:sub>\n                    O activation site. The precisely controlled atomic ratio of Mo and Bi ensures that there is sufficient but not excessive active hydrogen provided for\n                    <jats:sup>15<\/jats:sup>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212<\/jats:sup>\n                    hydrogenation and therefore accelerates the reaction rate. Moreover, Mo incorporation increases the energy barrier of\n                    <jats:sup>15<\/jats:sup>\n                    NH\n                    <jats:sub>2<\/jats:sub>\n                    OH overhydrogenation and thus improves the Faradaic efficiency (FE) of\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010oxime. This strategy enables scale\u2010up electrosynthesis with a 76% FE and 88% yield at a current of 3.0 A to obtain 3.5 g of\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010cyclohexanone oxime within 1.5 h. The application potential is highlighted by the methodological universality of diverse\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010oximes, the extended synthesis of\n                    <jats:sup>15<\/jats:sup>\n                    N\u2010labeled drug molecules and their application in 2D magnetic resonance imaging visualization.\n                  <\/jats:p>","DOI":"10.1002\/anie.202516528","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T04:50:23Z","timestamp":1756702223000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ampere\u2010Level Electrosynthesis of\n                    <sup>15<\/sup>\n                    N\u2010Labeled Oximes by Alloy Synergy Activation and Hydroxylamine Overhydrogenation Inhibition"],"prefix":"10.1002","volume":"64","author":[{"given":"Jinghui","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Molecular Plus Department of Chemistry School of Science Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Plus Department of Chemistry School of Science Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuibo","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Plus Department of Chemistry School of Science Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-1819","authenticated-orcid":false,"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Molecular Plus Department of Chemistry School of Science Tianjin University  Tianjin 300072 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Plus Department of Chemistry School of Science Tianjin University  Tianjin 300072 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