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However, such synthesis suffers from limited selectivity due to the complex reaction pathways. In this study, we report the highly selective synthesis of glycine from the electrocatalytic co\u2010reduction of nitrate and glyoxylic acid via stabilizing the intermediates of NH\n                    <jats:sub>2<\/jats:sub>\n                    OH and optimizing the absorption of glyoxylic acid on copper\u2010based model catalysts. Theoretical calculations and operando measurements indicate that CuSn alloys promote the generation of NH\n                    <jats:sub>2<\/jats:sub>\n                    OH and optimize the absorption of glyoxylic acid, thereby facilitating the precise coupling of C\u2013N groups to synthesize glycine. Consequently, the CuSn electrocatalyst delivers an excellent performance for the co\u2010reduction to generate glycine with a maximum Faradaic efficiency and selectivity of 78.69% and 99.32%, respectively. Moreover, the CuSn catalyst enables the production of 0.73\u00a0g of glycine with a conversion rate of 100%, respectively, in large\u2010scale synthesis. Techno\u2010economic analysis reveals that the total cost for the proposed method is 1158.88 $ ton\n                    <jats:sup>\u22121<\/jats:sup>\n                    , 1.78\u2010fold lower than the commercial price (2060.44 $ ton\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), suggesting that the electrosynthesis of glycine in our system is a feasible and profitable route.\n                  <\/jats:p>","DOI":"10.1002\/anie.202516749","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T14:10:42Z","timestamp":1763475042000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Highly Selective Electrosynthesis of Glycine from Glyoxylic Acid and Nitrate via Stabilizing the NH\n                    <sub>2<\/sub>\n                    OH Intermediates"],"prefix":"10.1002","volume":"65","author":[{"given":"Weiliang","family":"Zhou","sequence":"first","affiliation":[{"name":"Institute of Materials Research Tsinghua Shenzhen International Graduate School Tsinghua University  Shenzhen Guangdong 518055 P.R. 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