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However, perovskites generally demonstrate poor stability at ambient conditions, limiting their applications for SERS bioanalysis. Herein, we created a perovskite\u2010based heterostructure through effectively passivating defects at the interface with hydrophobic organic semiconductors, which simultaneously enhanced the stability and efficiency of perovskite SERS substrate. The significant enhancement factor of 10\n                    <jats:sup>7<\/jats:sup>\n                    was mainly stemmed from the resonance Raman effect and the highly\u2010efficient charge transfer process driven by a novel light\u2010induced hot electron transfer mechanism in plasmon\u2010free substrates previously never reported. This system was subsequently developed as an integrated theranostic SERS platform for miR\u2010146a monitoring with a detection limit down to 0.2\u00a0fM, successfully guiding the early theranostics to enhance the therapeutic efficiency for Alzheimer's disease (AD). This work brings new light into the design of efficient and stable semiconductor SERS substrate and opens novel diagnosis and treatment options for AD.\n                  <\/jats:p>","DOI":"10.1002\/anie.202518319","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T07:13:06Z","timestamp":1762240386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010Efficient Raman Enhancement on Organic Semiconductor\u2010Stabilized Perovskite Heterostructures for Guiding Early Theranostics of Alzheimer's Disease"],"prefix":"10.1002","volume":"65","author":[{"given":"Qing","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 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Dongchuan Road 500 Shanghai 200241 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 China"},{"name":"Shanghai Frontiers Science Center of Molecule Intelligent Syntheses School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University  Xianlin Road 163 Nanjing 210093 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-2180","authenticated-orcid":false,"given":"Tingting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 500 Shanghai 200241 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University  Dongchuan Road 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