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However, developing a practical strategy to produce such high\u2010valued chemicals from widely abundant materials, such as ketones, remains elusive. Herein, we present a stereodivergent deacylative Mizoroki\u2013Heck reaction of methyl ketones and cyclic ketones to furnish both\n                    <jats:italic>E<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010configured alkenes via dual photoredox\/cobalt catalysis. Interestingly, the tunable\n                    <jats:italic>E<\/jats:italic>\n                    \/\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010selectivity is achieved by energy transfer catalysis via the judicious choice of photocatalyst. This versatile strategy features a broad substrate scope with excellent functional group tolerance and is suitable for late\u2010stage modification of complex molecules and the one\u2010pot operation. It also expands the reaction profiles of both deacylative transformation and photoredox\/cobalt catalysis.\n                  <\/jats:p>","DOI":"10.1002\/anie.202518599","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:30:16Z","timestamp":1763044216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Stereodivergent Deacylative Mizoroki\u2013Heck Reaction of Unstrained Ketones"],"prefix":"10.1002","volume":"65","author":[{"given":"Kaihang","family":"Wei","sequence":"first","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou 310024 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulian","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study University of 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