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Herein, we present the first Osmium(II)\u2010Platinum(IV)\u2010Ceritinib conjugate (\n                    <jats:bold>Os\u2010Pt\u2010Cer<\/jats:bold>\n                    ) that synergistically combines photodynamic therapy (PDT), chemotherapy, and immunotherapy via immunogenic cell death (ICD) induction. This heterobimetallic complex features a photoactive osmium(II) polypyridyl core, a platinum(IV) prodrug derived from oxaliplatin, and the kinase inhibitor ceritinib as an axial ligand. Upon deep\u2010red irradiation (\n                    <jats:italic>\u03bb<\/jats:italic>\n                    = 740\u00a0nm), the conjugate exhibits potent antiproliferative activity in ovarian 2D cancer cells and 3D tumour spheroids, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the low nanomolar range. In addition,\n                    <jats:bold>Os\u2010Pt\u2010Cer<\/jats:bold>\n                    effectively inhibits cancer cell migration. Mechanistic studies reveal that the conjugate induces hallmarks of ICD, including calreticulin exposure, ATP release, HMGB1 secretion and phagocytosis. This multifunctional approach highlights the potential of osmium(II)\u2010platinum(IV) conjugates as promising candidates for overcoming resistance and immune evasion in high\u2010grade ovarian carcinoma.\n                  <\/jats:p>","DOI":"10.1002\/anie.202518623","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:57:47Z","timestamp":1759733867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A Triple Threat Against Ovarian Cancer: Os(II)\u2010Pt(IV)\u2010Ceritinib Conjugates for Photodynamic Therapy, Chemotherapy, and Immunogenic Cell Death Induction"],"prefix":"10.1002","volume":"64","author":[{"given":"Marta","family":"Redrado","sequence":"first","affiliation":[{"name":"Chimie ParisTech Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, PSL University, CNRS  Paris 75005 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