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Herein, we report an efficient polyoxometalate (POM)\u2010directed self\u2010assembly strategy enabling the selective assembly of robust Pt\n                    <jats:sub>6<\/jats:sub>\n                    L\n                    <jats:sub>4<\/jats:sub>\n                    cages under thermodynamic or kinetic control, which is inaccessible via untemplated methods. For a planar ligand (\n                    <jats:bold>L1<\/jats:bold>\n                    ) with a dihedral angle (\u03b8 = 0\u00b0), the POM template promotes the formation of a thermodynamically favored Pt\n                    <jats:sub>6<\/jats:sub>\n                    (\n                    <jats:bold>L1<\/jats:bold>\n                    )\n                    <jats:sub>4<\/jats:sub>\n                    analog. Remarkably, for a twisted and flexible ligand (\n                    <jats:bold>L2<\/jats:bold>\n                    ) with a nonideal dihedral angle (\u03b8 \u2248 36\u00b0), which typically favors the thermodynamically preferred M\n                    <jats:sub>12<\/jats:sub>\n                    L\n                    <jats:sub>8<\/jats:sub>\n                    cages, the POM template induces the formation of the kinetically trapped M\n                    <jats:sub>6<\/jats:sub>\n                    L\n                    <jats:sub>4<\/jats:sub>\n                    cages even when using inert Pt(II) precursors. In the absence of POMs, such structures cannot form due to conformational mismatch and the kinetic inertness of metal\u2010ligand coordination. The resulting Pt(II)\u2010based cages are highly stable and remain intact as discrete, template\u2010free hosts after POM removal, capable of encapsulating diverse guests in both acidic and basic aqueous media. This work highlights the unique templating role of POMs in accessing both thermodynamic and kinetic architectures, offering new opportunities for designing robust cages for drug delivery, sensing, and catalysis under harsh conditions.\n                  <\/jats:p>","DOI":"10.1002\/anie.202518649","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T11:49:24Z","timestamp":1760096964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Polyoxometalate\u2010Directed Assembly of Robust Coordination Cages: Overcoming Kinetic Inertness and Conformational Mismatch"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-0094","authenticated-orcid":false,"given":"Cui\u2010Lian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Chemistry KU Leuven  Celestijnenlaan 200F Leuven 3001 Belgium"},{"name":"Van \u2019t Hoff Institute for Molecular Sciences University of Amsterdam  Science Park 904 Amsterdam 1098 XH The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-687X","authenticated-orcid":false,"given":"Xu","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Celestijnenlaan 200F Leuven 3001 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-2720","authenticated-orcid":false,"given":"Rens","family":"Ham","sequence":"additional","affiliation":[{"name":"Van \u2019t Hoff Institute for Molecular Sciences University of Amsterdam  Science Park 904 Amsterdam 1098 XH The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9518-3625","authenticated-orcid":false,"given":"Chongting","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Celestijnenlaan 200F Leuven 3001 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2186-5209","authenticated-orcid":false,"given":"Luc","family":"Van Meervelt","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven  Celestijnenlaan 200F Leuven 3001 Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5024-508X","authenticated-orcid":false,"given":"Joost N. 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