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While the biological functions of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    have received much attention, their exact action mechanisms are still poorly understood due to the lack of reliable detection methods. In this context, fluorescent probes for H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    are emerging as powerful chemical tools to aid in unraveling its contributions to biology. Currently, most available H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    probes are prone to interference from biothiols or hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S). To address this challenge, herein, we report a unique carbonothioate\u2010based trigger utilizing a cascade cyclization reaction for specific detection of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    . Using this strategy, eight new fluorescent probes (\n                    <jats:bold>CTP 1\u20138<\/jats:bold>\n                    ) were prepared and evaluated. Among them,\n                    <jats:bold>CTP\u20108<\/jats:bold>\n                    not only enables highly sensitive and selective detection of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    but also allows visualization of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    fluctuations in living cells and mice. Significantly, we demonstrate for the first time the fluorescence imaging of endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    dynamics in insulin\u2010resistant cells and type 2 diabetes mellitus (T2DM) mice. Besides, this carbonothioate\u2010based trigger could also be potentially utilized in other fluorescent dye scaffolds that possess an optically tunable phenolic hydroxyl group. This work provides a useful approach for further investigations of H\n                    <jats:sub>2<\/jats:sub>\n                    S\n                    <jats:sub>n<\/jats:sub>\n                    biology as well as future probe development.\n                  <\/jats:p>","DOI":"10.1002\/anie.202519021","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T11:25:26Z","timestamp":1760181926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Carbonothioate\u2010Triggered Cascade Cyclization Enables High\u2010Specificity Fluorescence Imaging of Hydrogen Polysulfides"],"prefix":"10.1002","volume":"64","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"He","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minrong","family":"Huang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals &amp; MOE Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University  Wuhan 430062 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Liu","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"He","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deming","family":"He","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology  Wuhan 430074 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals &amp; MOE Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University  Wuhan 430062 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