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In this field, CADA of arenols, especially 2\u2010naphthols with diversified external electrophiles has been well established, however the oxidative CADA of 2\u2010naphthols with an external nucleophile, proceeding via an initial SET\u2010oxidation to reverse its polarity, is rare. Herein, we report our recent development on the copper\/chiral diamine\u2010catalyzed kinetic spirocyclization of 2\u2010naphthols under ambient conditions, in which the axial and spiro\u2010central elements of chirality could be simultaneously achieved in a one\u2010step kinetic resolution process. The robust nature of the oxidative CADA strategy is reflected by a broad scope of 2\u2010naphthol substrates with good control of the enantioselectivity. DFT calculations suggested that the anion of chloride played a crucial role in the control of enantioselectivity by forming hydrogen bonds with the hydroxyl group in the substrate and the diamine ligand. The matched coordination of naphthol substrates with chiral copper(II) catalyst leads to the subsequent oxidation to access the latter stereospecific spirocyclization.<\/jats:p>","DOI":"10.1002\/anie.202519818","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T07:04:40Z","timestamp":1762153480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anion\u2010Assisted Copper\/Chiral Diamine\u2010Catalyzed Aerobic Oxidation for the Kinetic Dearomative Spirocyclization of Arenols"],"prefix":"10.1002","volume":"64","author":[{"given":"Tianyu","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry Fudan University  2005 Songhu Road Shanghai 200438 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Engineering Biology for Low\u2010Carbon Manufacturing Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences  Tianjin 300308 P.R. 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