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Here, we report that a PDPP (4\u2010(piperidin\u20101\u2010yl)pyridine) and copper synergistically catalyzed nitrogenation of benzoic acids with a tailored nitrogenation reagent. This protocol efficiently enables the selective decarboxylation and benzene ring opening processes leading to acyclic dinitrile products. The designed new azide reagent plays an essential role in the PDPP\u2010catalyzed initial step to trigger the selective carboxyl and aromatic C\u2500C bond cleavage process. This synergistic strategy greatly expands the synthetic utility of benzoic acids, providing a direct and practical route to acyclic scaffolds. The aromatic ring\u2010opening products could be further used in cyclization reactions to realize phenyl ring scaffold hopping.<\/jats:p>","DOI":"10.1002\/anie.202520084","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:45:28Z","timestamp":1762271128000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decarboxylative Arene Ring\u2010Opening of Benzoic Acids"],"prefix":"10.1002","volume":"65","author":[{"given":"Ming\u2010Hui","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Center School of Pharmaceutical Sciences Peking University  Xue Yuan Rd. 38 Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengrui","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Center School of Pharmaceutical Sciences Peking University  Xue Yuan Rd. 38 Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilei","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Center School of Pharmaceutical Sciences Peking University  Xue Yuan Rd. 38 Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Center School of Pharmaceutical Sciences Peking University  Xue Yuan Rd. 38 Beijing 100191 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-9034","authenticated-orcid":false,"given":"Ning","family":"Jiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs Chemical Biology Center School of Pharmaceutical Sciences Peking University  Xue Yuan Rd. 38 Beijing 100191 China"},{"name":"State Key Laboratory of Organometallic Chemistry Sciences Chinese Academy of Sciences  Shanghai 200032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"AgileIntel Research (ChemIntel360). 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