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Although synthetic chemists have achieved significant advancements in the cross\u2010coupling of stable C(sp\n                    <jats:sup>3<\/jats:sup>\n                    ) substrates, such as aliphatic carboxylic acids and alkyl halides, cost\u2010effective, accessible, and versatile sources of alkyl groups, specifically alcohols, remain underutilized. The direct deoxygenation of alcohols under mild circumstances presents a significant challenge in organic synthesis, primarily due to the absence of an efficient mechanism for the direct activation of C\u2500O bonds. Consequently, there is an imperative necessity for chemists to devise a multifaceted approach for the cross\u2010coupling of alcohols. This study aims to utilize neutral diphenylboron radicals as hydroxyl activation agents to directly activate the carbon\u2013oxygen bonds of prevalent alcohols, thereby generating alkyl radicals, which are subsequently involved in nickel\u2010catalyzed arylation processes. Both free alcohols and aryl bromides, which are easily accessible compounds, can serve as coupling partners directly without requiring pre\u2010functionalization. The direct arylation process of alcohols exhibits a broad substrate scope, as demonstrated by the subsequent arylation of several structurally intricate natural compounds and pharmaceuticals.\n                  <\/jats:p>","DOI":"10.1002\/anie.202520148","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:16:57Z","timestamp":1762157817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Direct Deoxyarylation of Non\u2010Activated Alcohols"],"prefix":"10.1002","volume":"64","author":[{"given":"Qiumei","family":"Pan","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Zhejiang Sci\u2010Tech University  Hangzhou 310018 P.R. 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