{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T07:45:37Z","timestamp":1792395937236,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22371252"],"award-info":[{"award-number":["22371252"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Organic solvent nanofiltration (OSN) membranes play a crucial role in the manufacturing of active pharmaceutical ingredients (APIs). The synthesis process of APIs typically contains low molecular weight genotoxic impurities (GTIs) that compromise product quality. However, current OSN membranes face significant technical challenges in separating high\u2010value APIs with molecular weights (MW) below 350\u00a0g mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    due to their lack of precisely controlled pore structures. Porous organic cages (POCs), a class of discrete organic molecules with permanent three\u2010dimensional cavities, feature ordered pore structures, good processability and modularity, making them ideal candidates for fabricating membranes with highly tunable pore structures for precise separations. Here, we report the fabrication of porous network membranes via nucleophilic substitution reactions of POCs. These membranes, with retaining incorporated cavities, exhibit high methanol permeance and excellent dye rejection (&gt;94% for APIs with MW above 368\u00a0g mol\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), outperforming commercial OSN membranes. Importantly, they achieve a selectivity of 13 in removing GTIs from APIs, thereby producing high\u2010purity APIs. This work highlights the great potential of the POCs\u2010based membranes for precision pharmaceutical separations.\n                  <\/jats:p>","DOI":"10.1002\/anie.202520819","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:01:22Z","timestamp":1766048482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Networked Porous Organic Cage Membranes for Precision Separation of Pharmaceutical Ingredients"],"prefix":"10.1002","volume":"65","author":[{"given":"Saisai","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Chemistry Zhejiang University  866 Yuhangtang Road Hangzhou 310058 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Zhejiang University  866 Yuhangtang Road Hangzhou 310058 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Chemistry Zhejiang University  866 Yuhangtang Road Hangzhou 310058 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyi","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Chemistry Zhejiang University  866 Yuhangtang Road Hangzhou 310058 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutao","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Chemistry Zhejiang University  866 Yuhangtang Road Hangzhou 310058 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-1480","authenticated-orcid":false,"given":"Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Zhejiang University  866 Yuhangtang Road Hangzhou 310058 P.R. China"},{"name":"Zhejiang Key Laboratory of Intelligent Manufacturing for Functional Chemicals ZJU\u2010Hangzhou Global Scientific and Technological Innovation Center Zhejiang University  2118 Pinglan Road Hangzhou 311215 P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422333"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207559"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2011.07.007"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr9260"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202001132"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010018\u20100093\u20109"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b08788"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202421661"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047115\u20109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202212816"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4638"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CS00919H"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi1545"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202316093"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4TA00628C"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2012.03.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b05155"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005032\u20101"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41893\u2010025\u201001570\u20104"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2545"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax7427"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201505688"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202409296"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202420086"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010021\u201001168\u2010z"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315750"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038728\u20107"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314469"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046809\u20104"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TA09632C"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201051548\u20107"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2024.123227"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201705933"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202406430"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202413046"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c17878"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07732"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.4c00701"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201064056\u2010z"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2019.04.027"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh2404"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.1c02919"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44221\u2010023\u201000162\u2010w"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201019404\u20106"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.memsci.2019.117505"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202520819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202520819","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202520819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:33:17Z","timestamp":1779438797000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202520819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,2,2]]}},"alternative-id":["10.1002\/anie.202520819"],"URL":"https:\/\/doi.org\/10.1002\/anie.202520819","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"assertion":[{"value":"2025-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e20819"}}