{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:25:44Z","timestamp":1783427144972,"version":"3.54.6"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The influence of host\u2013guest interactions on the physical behavior of encapsulated species represents a compelling area of study. Research in this domain has predominantly centered on how these interactions affect catalytic activity and the photoluminescence properties of confined guest molecules. In contrast, their potential impact on antibacterial and antibiofilm activity has been rare. In this report, we present antibacterial and antibiofilm activity of a Pd\n                    <jats:sub>8<\/jats:sub>\n                    low\u2010symmetric molecular barrel (\n                    <jats:bold>LSMB<\/jats:bold>\n                    ) based host\u2013guest system (\n                    <jats:bold>TPH\u2282LSMB<\/jats:bold>\n                    ) in water. The new low\u2010symmetric ligand (\n                    <jats:bold>L<\/jats:bold>\n                    ) upon self\u2010assembly with a\n                    <jats:italic>cis\u2010<\/jats:italic>\n                    Pd(II) acceptor generated a tetrafacial low\u2010symmetrical barrel (\n                    <jats:bold>LSMB<\/jats:bold>\n                    ). Encapsulation of a guest\n                    <jats:bold>TPH<\/jats:bold>\n                    [1,4\u2010bis(2,2\u2010diphenylvinyl)benzene], which is otherwise non\u2010emissive in dilute solution, by\n                    <jats:bold>LSMB<\/jats:bold>\n                    resulted in a remarkable increase in its emission intensity even in very dilute aqueous conditions. The host\u2013guest complex (\n                    <jats:bold>TPH\u2282LSMB)<\/jats:bold>\n                    shows better antibacterial and antibiofilm activity compared to the host (\n                    <jats:bold>LSMB<\/jats:bold>\n                    ). More interestingly,\n                    <jats:bold>TPH\u2282LSMB<\/jats:bold>\n                    shows better antibacterial and antibiofilm activity against Gram\u2010negative bacterial strains as compared to Gram\u2010positive strains. This selectivity against Gram\u2010negative strains provides a critical advancement in the rational design of supramolecular antibacterial and antibiofilm agents. The findings provide valuable insights for the development of next\u2010generation, light\u2010independent therapeutic systems specifically tailored to overcome the inherent challenges posed by Gram\u2010negative pathogens.\n                  <\/jats:p>","DOI":"10.1002\/anie.202521285","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:42:34Z","timestamp":1766122954000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dual\u2010Function Antibacterial and Antibiofilm Agent Based on a Confinement\u2010Activated Fluorescent System in Water"],"prefix":"10.1002","volume":"65","author":[{"given":"Dharmraj","family":"Prajapati","sequence":"first","affiliation":[{"name":"Department of Inorganic and Physical Chemistry Indian Institute of Science  Bangalore 560012 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