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However, the poor C\u2500N coupling selectivity and limited Faradaic efficiency hinder practical application. As the critical step involves nucleophilic attack of NH\n                    <jats:sub>3<\/jats:sub>\n                    on in situ generated *CH\n                    <jats:sub>2<\/jats:sub>\n                    O intermediates, enhancing *CH\n                    <jats:sub>2<\/jats:sub>\n                    O electrophilicity while suppressing over\u2010oxidation is essential. Herein, Pd single atoms anchored on MnO\n                    <jats:sub>2<\/jats:sub>\n                    nanoarrays achieve state\u2010of\u2010the\u2010art Faradaic efficiency (62.6%) and carbon selectivity (80.2%) for anodic formamide synthesis. In situ characterization and theoretical simulations reveal dual enhancement mechanisms: Isolated Pd sites adopt end\u2010on *CH\n                    <jats:sub>2<\/jats:sub>\n                    O adsorption to expose the electrophilic carbon, while the MnO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced acidic microenvironment enhances *CH\n                    <jats:sub>2<\/jats:sub>\n                    O electrophilicity via oxygen\u2010atom protonation. This synergy accelerates nucleophilic attack by NH\n                    <jats:sub>3<\/jats:sub>\n                    , enabling efficient C\u2500N coupling.\n                  <\/jats:p>","DOI":"10.1002\/anie.202521334","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:00:21Z","timestamp":1768888821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Local Acidic Microenvironments Enhanced Anodic Formamide Electrosynthesis over Isolated Pd Sites"],"prefix":"10.1002","volume":"65","author":[{"given":"Baian","family":"Shen","sequence":"first","affiliation":[{"name":"Institute of Molecular Plus School of Chemical Engineering and Technology Tianjin University  Tianjin 300354 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering Sichuan University  Chengdu Sichuan 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