{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:12:33Z","timestamp":1790345553963,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["22\u201003945S"],"award-info":[{"award-number":["22\u201003945S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,5,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polyhedral carboranes are highly biologically stable, non\u2010toxic clusters. Whereas they are typically encountered in anionic or neutral forms, positively charged species have only recently been discovered. The in vitro antiproliferative effects of selected carboranes were assessed using a panel of human cancer cell lines, and off\u2010target toxicity was evaluated at normal cell lines. The results demonstrated significant anticancer activity and a favorable resistance factor (RF \u2248 1) for monocationic carborane\n                    <jats:bold>\n                      <jats:italic>o<\/jats:italic>\n                      \u20102a\n                    <\/jats:bold>\n                    , surpassing the effects of\n                    <jats:italic>doxorubicin<\/jats:italic>\n                    and\n                    <jats:italic>cisplatin<\/jats:italic>\n                    . In pursuit of even more efficient substrates, the first dicationic polyhedral boranes were synthesized. These water\u2010stable dications exhibit a reversible\n                    <jats:italic>closo\u2010<\/jats:italic>\n                    \/\n                    <jats:italic>nido\u2010<\/jats:italic>\n                    cage opening, triggered either by a strong base (DMAP) or by a combination of triethylamine and molecular hydrogen, and reversed upon the addition of acid. The former transformation proceeds without a redox change, while the latter involves a H\n                    <jats:sub>2<\/jats:sub>\n                    \/2H\n                    <jats:sup>+<\/jats:sup>\n                    conversion in a proton\u2010coupled electron process.\n                  <\/jats:p>","DOI":"10.1002\/anie.202521595","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:17:39Z","timestamp":1775117859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2825-7299","authenticated-orcid":false,"given":"Vlastimil","family":"N\u011bmec","sequence":"first","affiliation":[{"name":"Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice  Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Holub","sequence":"additional","affiliation":[{"name":"Institute of Inorganic Chemistry Czech Academy of Sciences  \u0158e\u017e Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maksim A.","family":"Samsonov","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice  Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zde\u0148ka","family":"R\u016f\u017ei\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice  Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Cva\u010dka","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences  Flemingovo n\u00e1m\u011bst\u00ed Praha Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-1192","authenticated-orcid":false,"given":"J\u00e1n","family":"Van\u010do","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Tr\u00e1vn\u00ed\u010dek","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Belza","sequence":"additional","affiliation":[{"name":"Regional Centre of Advanced Technologies and Materials Czech Advanced Technology and Research Institute Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Dvo\u0159\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Genetics Faculty of Sciences Palack\u00fd University  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vr\u00e1na","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice  Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"R\u016f\u017ei\u010dka","sequence":"additional","affiliation":[{"name":"Department of General and Inorganic Chemistry Faculty of Chemical Technology University of Pardubice  Pardubice Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Carboranes","author":"Grimes R. N.","year":"2016"},{"key":"e_1_2_7_3_1","volume-title":"Boron Science: New Technologies and Applications","author":"Hosmane N. S.","year":"2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-22282-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.8b00551"},{"key":"e_1_2_7_6_1","volume-title":"Handbook of Boron Science With Applications in Organometallics, Catalysis, Materials and Medicine: Boron in Materials Chemistry","author":"Hosmane N. S.","year":"2018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307583"},{"key":"e_1_2_7_8_1","volume-title":"Handbook of Boron Science With Applications in Organometallics, Catalysis, Materials and Medicine: Boron in Medicine","author":"Hosmane N. S.","year":"2018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119275602"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00663"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0158229"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201700209"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC02268G"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402369"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200900072"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202300759"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500199"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202300506"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202400018"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201081414\u2010x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00197B"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108548"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00152"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201803178"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202002963"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01818G"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1515\/pac\u20102014\u20101006"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic2023709"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/b700689f"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c09361"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c06159"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5QI00263J"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025277\u20100"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202419677"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c03251"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202201369"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b00964"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00015a035"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic50095a046"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/c29710000792"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar50108a004"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/c39830000706"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar00105a003"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200500402"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.202200163"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/a803175d"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo201085r"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10870\u2010019\u201000773\u2010w"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0DT04225K"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic4015306"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b05505"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0QI01353F"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201704860"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119951438.eibc2779"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09007"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00989a054"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00374"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101134\u20102"},{"key":"e_1_2_7_59_1","unstructured":"Deposition numbers 2487180 (foro\u20102c) 2487178 (foro\u20102d) 2487177 (o\u20102e) 2487175 (p\u20102Cy) 2487173 (p\u20102aiPr) 2487174 (forp\u20102aCy) 2487179 (forp\u20102bCy) and 2487176 (forp\u20102dCy) contain the supplementary crystallographic data for this paper. Copies of this information may be obtained free of charge from The Director CCDC 12 Union Road Cambridge CB2 1EY UK (fax: +44\u20101223\u2010336033; e\u2010mail:deposit@ccdc.cam.ac.ukor www:http:\/\/www.ccdc.cam.ac.uk)."},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.6b01386"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1135\/cccc20020949"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01006a008"},{"key":"e_1_2_7_63_1","first-page":"227","volume-title":"Inorganic Syntheses","author":"Holt S. L.","year":"1983"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.200500231"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol502583h"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314026370"},{"key":"e_1_2_7_67_1","unstructured":"M. J.FrischandG. W.Trucks Gaussian 16 Wallingford CT 2016."},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.464913"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.478522"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/b508541a"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9904009"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"e_1_2_7_73_1","unstructured":"T. A.Keith AIMAll (Version 19.10.12) T2019."}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202521595","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202521595","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202521595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:52:51Z","timestamp":1781693571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202521595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":72,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,5,11]]}},"alternative-id":["10.1002\/anie.202521595"],"URL":"https:\/\/doi.org\/10.1002\/anie.202521595","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"2025-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e21595"}}