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The reaction is catalyzed by a ruthenium pincer catalyst at 80 \u00b0C in bioderived solvents \u2013 a combination of 2\u2010methyl THF and ethanol. A detailed mechanistic investigation through organometallic and kinetic studies, as well as chemical exchange saturation transfer (CEST) NMR spectroscopy, provides insights into the nature of active species and factors that promote and inhibit the catalytic hydrogenation of PET. Using this mechanistic knowledge, a record high turnover number of\u00a0&gt;30\u00a0000 was achieved for the hydrogenative depolymerization of end\u2010of\u2010life PET waste (e.g., bottles and textiles). The semihydrogenation product, ethyl 4\u2010(hydroxymethyl)benzoate, was utilized to make precursors of various known pharmaceutical drugs, an agrochemical, as well as a new and recyclable polyester. A cradle\u2010to\u2010gate life cycle assessment demonstrated that using PET waste as a feedstock for EHMB production significantly reduces the environmental footprint compared to the conventional route from\n                    <jats:italic>p<\/jats:italic>\n                    \u2010toluic acid.\n                  <\/jats:p>","DOI":"10.1002\/anie.202521838","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:11:01Z","timestamp":1766056261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["From Plastic Waste to Pharmaceutical Precursors: PET Upcycling Through Ruthenium Catalyzed Semi\u2010Hydrogenation"],"prefix":"10.1002","volume":"65","author":[{"given":"Pavel S.","family":"Kulyabin","sequence":"first","affiliation":[{"name":"EaStCHEM School of Chemistry University of St Andrews  North Haugh, St Andrews KY16 9ST 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