{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:52:20Z","timestamp":1791888740297,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJCR20E6"],"award-info":[{"award-number":["JPMJCR20E6"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,4,27]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The expansion of specific repeat sequences causes dozens of heritable neuromuscular diseases, where expanded repeat RNAs play key roles in the pathogenic mechanism. Although the formation of RNA foci has been identified as a common hallmark of repeat diseases, their properties, dynamics, and mechanisms underlying toxicity remain elusive. Here, we demonstrate a novel strategy for the optical control of UGGAA repeat RNA foci, a pathological hallmark of spinocerebellar ataxia type 31 (SCA31), based on the modulation of RNA\u2013RNA interactions by a photoswitchable RNA\u2010binding ligand, NCTA. In the presence of NCTA, UV irradiation induced the growth of UGGAA repeat RNA foci in cells. Subsequent visible light irradiation dissolved the structure into the original smaller RNA foci. Reversible photoisomerization between\n                    <jats:italic>E<\/jats:italic>\n                    \u2010 and\n                    <jats:italic>Z<\/jats:italic>\n                    \u2010NCTA is responsible for the photocontrol of RNA foci, where Z\u2010NCTA stabilizes the association between UGGAAs. These changes were accompanied by alterations in the composition of RNA\u2010binding proteins within the RNA foci, suggesting that NCTA modulates their properties and functions by remodeling RNA foci. Our photocontrol system will be useful for investigating, manipulating and regulating dynamic structures containing RNA scaffolds, including disease\u2010related repeat RNA foci and membraneless ribonucleoprotein organelles.\n                  <\/jats:p>","DOI":"10.1002\/anie.202522077","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:30:54Z","timestamp":1773743454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phototriggered Morphological and Compositional Change of UGGAA Repeat RNA Foci by Photoswitchable RNA\u2010Binding Ligand"],"prefix":"10.1002","volume":"65","author":[{"given":"Yusuke","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Regulatory Bioorganic Chemistry SANKEN (The Institute of Scientific and Industrial Research) The University of Osaka, Osaka  Ibaraki 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