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Here, we report a synthetic strategy for developing ultra\u2010high metal loading SACs based on palladium polyphthalocyanine covalent organic frameworks (COFs) synthesized via a mixed metal ionothermal approach, which involves the cyclization of tetracyanobenzene and tetracyanopyrazine as precursors in molten salt mixtures of PdCl\n                    <jats:sub>2<\/jats:sub>\n                    \/ZnCl\n                    <jats:sub>2<\/jats:sub>\n                    or PdCl\n                    <jats:sub>2<\/jats:sub>\n                    \/ZnCl\n                    <jats:sub>2<\/jats:sub>\n                    \/NaCl. This approach effectively combines the formation of crystalline polymeric hosts with metal impregnation in a single step, yielding COFs with atomically distributed Pd ions and metal contents of up to 22.2\u00a0wt%. Theoretical simulations reveal that the crystalline framework dynamically confines Pd atoms between different binding sites within the pores, preventing dimerization and ensuring long\u2010term catalyst stability. The synthesized catalysts were evaluated under continuous flow conditions, exhibiting stable performance with yields as high as 90% and maintaining stability over a 24\u00a0h time\u2010on\u2010stream under low\u2010conversion conditions. These results establish a new benchmark for SACs and underscore the importance of dynamic confinement approach in achieving high metal loadings on crystalline organic supports.\n                  <\/jats:p>","DOI":"10.1002\/anie.202522238","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T06:02:26Z","timestamp":1767333746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dynamic Confinement Approach for High Metal Loading Single\u2010Atom Catalysts Based on Covalent Organic Frameworks"],"prefix":"10.1002","volume":"65","author":[{"given":"Kyung Seob","family":"Song","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Fribourg  Chemin du Musee 9 Fribourg 1700 Switzerland"},{"name":"National Centre of Competence in Research (NCCR) Catalysis University of Fribourg  Fribourg 1700 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murad","family":"Najafov","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Fribourg  Chemin du Musee 9 Fribourg 1700 Switzerland"},{"name":"National Centre of Competence in Research (NCCR) Catalysis University of Fribourg  Fribourg 1700 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel Gonz\u00e1lez","family":"Acosta","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica (ICIQ\u2010CERCA)  Av. Pa\u00efsos Catalans, 16 \u2013 Tarragona 43007 Spain"},{"name":"Department of Physical and Inorganic Chemistry Universitat Rovira i Virgili  Marcel\u00b7l\u00ed Domingo s\/n Tarragona 43007 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Ruiz","family":"Ferrando","sequence":"additional","affiliation":[{"name":"Institut Catal\u00e0 d'Investigaci\u00f3 Qu\u00edmica (ICIQ\u2010CERCA)  Av. 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