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Its overexpression is associated with various aggressive cancers, including triple\u2010negative breast cancer (TNBC) and pancreatic cancer, making it a promising target for diagnostic imaging. Besides antibodies, small\u2010molecule CD73 inhibitors have been developed and are currently in clinical trials. This study aimed to develop and evaluate fluorine\u201018 labeled high\u2010affinity CD73 inhibitors as tracers for the non\u2010invasive positron emission tomography (PET) imaging of CD73 expression in cancer. Two CD73 inhibitors were selected for radiolabeling based on their high potency (K\n                    <jats:sub>i<\/jats:sub>\n                    values of ca. 1\u00a0nM) and favorable pharmacokinetic properties, yielding [\n                    <jats:sup>18<\/jats:sup>\n                    F]PSB\u201019427 ([\n                    <jats:sup>18<\/jats:sup>\n                    F]\n                    <jats:bold>1<\/jats:bold>\n                    ) and [\n                    <jats:sup>18<\/jats:sup>\n                    F]MRS\u20104648 ([\n                    <jats:sup>18<\/jats:sup>\n                    F]\n                    <jats:bold>2<\/jats:bold>\n                    ). Ex vivo imaging studies on human breast cancer tissues indicated specific binding of both radiotracers. Subsequent in vivo studies proved [\n                    <jats:sup>18<\/jats:sup>\n                    F]\n                    <jats:bold>1<\/jats:bold>\n                    to be superior due to its long elimination half\u2010life and its accumulation in TNBC and pancreatic cancer tissues, suggesting its potential as a versatile PET tracer for imaging of various solid tumors. Compared to [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG, [\n                    <jats:sup>18<\/jats:sup>\n                    F]\n                    <jats:bold>1<\/jats:bold>\n                    was superior in visualizing TNBC, offering potential advantages over [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG in terms of specificity and diagnostic accuracy. Thus, [\n                    <jats:sup>18<\/jats:sup>\n                    F]\n                    <jats:bold>1<\/jats:bold>\n                    is a PET tracer with outstanding properties suitable for broad application in cancer diagnosis and personalized medicine.\n                  <\/jats:p>","DOI":"10.1002\/anie.202522758","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:30:48Z","timestamp":1773642648000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fluorine\u201018\u2010Labeled Nucleotide Analogs Targeting Ecto\u20105'\u2010Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors"],"prefix":"10.1002","volume":"65","author":[{"given":"Clemens","family":"Dobelmann","sequence":"first","affiliation":[{"name":"European Institute for Molecular Imaging (EIMI) University of Muenster  M\u00fcnster 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