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Targeted isolation yielded eight merocytochalasans, including four new compounds (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    \u2010\n                    <jats:bold>6<\/jats:bold>\n                    ), structurally characterized by MS, NMR, and x\u2010ray single\u2010crystal diffraction data analysis. Compound\n                    <jats:bold>1<\/jats:bold>\n                    possessing a unique cage\u2010like symmetrical skeleton, effectively suppressed growth, adhesion, and virulence of methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA), demonstrated potent efficacy in reducing bacterial burden in a mouse skin infection model, and exhibited low resistance development potential. Mechanistically,\n                    <jats:bold>1<\/jats:bold>\n                    binds the transmembrane component of the ABC transporter TarGH, and inhibiting its ATPase activity.\n                  <\/jats:p>","DOI":"10.1002\/anie.202523303","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:29:27Z","timestamp":1769592567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iizuchalasin A: A Marine Fungal Metabolite With a Cage\u2010Like Structure That Binds TarG to Inhibit Wall Teichoic Acid Biosynthesis by Multidrug\u2010Resistant\n                    <i>S. aureus<\/i>"],"prefix":"10.1002","volume":"65","author":[{"given":"Rui","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"},{"name":"State Key Laboratory of Microbial Diversity and Innovative Utilization Beijing 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Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzu","family":"Sun","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Diversity and Innovative Utilization Beijing Key Laboratory of Antimicrobial\u2010Resistant Pathogen Microbiology and AI\u2010Empowered Containment Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Medical School University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Diversity and Innovative Utilization Beijing Key Laboratory of Antimicrobial\u2010Resistant Pathogen Microbiology and AI\u2010Empowered Containment Institute of Microbiology Chinese Academy of Sciences  Beijing China"},{"name":"Medical School University of Chinese Academy of Sciences  Beijing 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