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Receptors capable of both strong sulfate binding and efficient transport are rare. Macrocycles\n                    <jats:bold>c5<\/jats:bold>\n                    , featuring a constrained aromatic amide backbone that convergently locks multiple amide NH and phenyl NH donors, along with five large amide dipoles, create a preorganized, electropositive cavity that binds sulfate in a 1:1 stoichiometry, with affinities (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>a<\/jats:sub>\n                    \u2019s) from 10\n                    <jats:sup>8<\/jats:sup>\n                    to 10\n                    <jats:sup>13<\/jats:sup>\n                    M\n                    <jats:sup>\u22121<\/jats:sup>\n                    in solvents of low to high polarity. The water\u2010soluble\n                    <jats:bold>c5c<\/jats:bold>\n                    binds sulfate, forming a 4:1 complex in aqueous solution. Macrocycles\n                    <jats:bold>c5a<\/jats:bold>\n                    and\n                    <jats:bold>c5b<\/jats:bold>\n                    with hydrophobic sidechains serve as carriers that mediate efficient sulfate transport across both a bulk chloroform phase and lipid bilayers. With their synthetic tunability, macrocycles\n                    <jats:bold>c5<\/jats:bold>\n                    can be tailored to media of different properties, yielding effective sulfate binders and carriers with broad applicability.\n                  <\/jats:p>","DOI":"10.1002\/anie.202523430","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T06:04:34Z","timestamp":1765951474000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aromatic Pentaamide Macrocycles as High\u2010Affinity Sulfate Binders and Efficient Transporters"],"prefix":"10.1002","volume":"65","author":[{"given":"Danbo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry University at Buffalo The State University of New York  Buffalo New York 14260 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