{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:10:31Z","timestamp":1789575031649,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["ESGENT\/2024\/001"],"award-info":[{"award-number":["ESGENT\/2024\/001"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIDEGENT\/2020\/031"],"award-info":[{"award-number":["CIDEGENT\/2020\/031"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIPROM\/2021\/007"],"award-info":[{"award-number":["CIPROM\/2021\/007"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CP23\/00086"],"award-info":[{"award-number":["CP23\/00086"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A study of the Pd\u2010based molecular cage\n                    <jats:bold>C1<\/jats:bold>\n                    host\u2013guest properties against fluorescein and the drug scopolamine is reported.\n                    <jats:bold>C1<\/jats:bold>\n                    forms an interpenetrated structure\n                    <jats:bold>\n                      C1\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:bold>\n                    in the presence of\u00a0\u226540% water in H\n                    <jats:sub>2<\/jats:sub>\n                    O\/DMSO solvent mixtures. The presence of fluorescein (FL) induces the disassembly of the\n                    <jats:bold>\n                      C1\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:bold>\n                    structure to form the\n                    <jats:bold>\n                      [FL\n                      <jats:sub>2<\/jats:sub>\n                      \u2282C1]\n                    <\/jats:bold>\n                    complex. Moreover, the addition of scopolamine (SCOP, a drug typically involved in drug\u2010facilitated sexual assaults) to\n                    <jats:bold>\n                      [FL\n                      <jats:sub>2<\/jats:sub>\n                      \u2282C1]\n                    <\/jats:bold>\n                    results in fluorescein release and the formation of [\n                    <jats:bold>\n                      SCOP\u2282C1\n                      <jats:sub>2<\/jats:sub>\n                    <\/jats:bold>\n                    ], obtaining a fluorescence signal proportional to the concentration of scopolamine with a limit of detection as low as 59.4\u00a0\u00b5g mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    . A good selectivity for scopolamine against other drugs such as MDMA, cocaine, GBL, and ketamine is observed. This is the first scopolamine detection method described to date using a molecular cage and one of the very few examples of the use of cages in indicator displacement assays. Similar concepts could be applied to the design of other molecular cage\u2010based sensors for the detection of target analytes.\n                  <\/jats:p>","DOI":"10.1002\/anie.202523575","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:58:44Z","timestamp":1765961924000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Cages as Probes in Indicator Displacement Assays: The Case of Scopolamine Detection"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-9937","authenticated-orcid":false,"given":"Giovanni","family":"Mont\u00e0\u2010Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia Camino de Vera s\/n Valencia 46022 Spain"},{"name":"Departamento de Qu\u00edmica Universitat Polit\u00e8cnica de Val\u00e8ncia  Camino de Vera s\/n Valencia 46022 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-1419","authenticated-orcid":false,"given":"Eva","family":"Garrido","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia Camino de Vera s\/n Valencia 46022 Spain"},{"name":"Departamento de Qu\u00edmica Universitat Polit\u00e8cnica de Val\u00e8ncia  Camino de Vera s\/n Valencia 46022 Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6128-1235","authenticated-orcid":false,"given":"Estela","family":"Climent","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia Camino de Vera s\/n Valencia 46022 Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en Nanomedicina y Sensores Universitat Polit\u00e8cnica de Val\u00e8ncia Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe) Avenida Fernando Abril Martorell 106 Valencia 46026 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8288-0384","authenticated-orcid":false,"given":"Cristian","family":"Vicent","sequence":"additional","affiliation":[{"name":"Serveis Centrals d'Instrumentaci\u00f3 Cient\u00edfica Universitat Jaume I  Avenida Sos Baynat s\/n Castell\u00f3 de la Plana 12071 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-9674","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Mart\u00ednez\u2010M\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia Camino de Vera s\/n Valencia 46022 Spain"},{"name":"Departamento de Qu\u00edmica Universitat Polit\u00e8cnica de Val\u00e8ncia  Camino de Vera s\/n Valencia 46022 Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"},{"name":"Unidad Mixta de Investigaci\u00f3n en Nanomedicina y Sensores Universitat Polit\u00e8cnica de Val\u00e8ncia Instituto de Investigaci\u00f3n Sanitaria La Fe (IIS La Fe) Avenida Fernando Abril Martorell 106 Valencia 46026 Spain"},{"name":"Unidad Mixta UPV\u2010CIPF de Investigaci\u00f3n en Mecanismos de Enfermedades y Nanomedicina Universitat Polit\u00e8cnica de Val\u00e8ncia Centro de Investigaci\u00f3n Pr\u00edncipe Felipe  Avenida Eduardo Primo Y\u00fafera 3 Valencia 46012 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9142-9392","authenticated-orcid":false,"given":"Vicente","family":"Mart\u00ed\u2010Centelles","sequence":"additional","affiliation":[{"name":"Instituto Interuniversitario de Investigaci\u00f3n de Reconocimiento Molecular y Desarrollo Tecnol\u00f3gico (IDM) Universitat Polit\u00e8cnica de Val\u00e8ncia Universitat de Val\u00e8ncia Camino de Vera s\/n Valencia 46022 Spain"},{"name":"Departamento de Qu\u00edmica Universitat Polit\u00e8cnica de Val\u00e8ncia  Camino de Vera s\/n Valencia 46022 Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina (CIBER\u2010BBN) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"United Nations Office on Drugs and Crime (UNODC) World Drug Report 2024 United Nations Office on Drugs and Crime 2024 https:\/\/www.unodc.org\/documents\/data\u2010and\u2010analysis\/WDR_2024\/WDR24_Key_findings_and_conclusions.pdf(accessed: October2025)."},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jflm.2021.102151"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2023.111806"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2024.136228"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsisyn.2024.100545"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2022.133043"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2nr03325a"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00615"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/open.201800034"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3cp00524k"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116006"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.3605"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2024.2435335"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127617"},{"key":"e_1_2_8_15_1","volume-title":"Indicator Displacement Assays (IDAs): An Innovative Molecular Sensing Approach","author":"Rather I. A.","year":"2024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1ob00518a"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201600226"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201100359"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8nr03132k"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c06287"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2021.113454"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.4c00934"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201300098"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8sc05527k"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40242\u2010022\u20102244\u20101"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2022.153676"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252211861"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00198"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202000574"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29071621"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/targets2040021"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00056"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/10610278.2024.2398575"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3cc04522f"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8nj02156b"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1sc04272f"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9cc05613k"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202205403"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4sc04950k"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1qo00517k"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202203887"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202300872"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trechm.2025.06.006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4sc02294g"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010025\u201000721\u20107"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004\u2010025\u201001493\u20103"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239217"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/21861"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.03.037"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201806047"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0dt01674h"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.7b00231"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200703162"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201107184"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/ceur.202300047"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00167B"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/bms.1200220902"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202112513"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.21585"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0cs01550d"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.78"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp066953m"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcp.2013.05.038"},{"key":"e_1_2_8_64_1","volume-title":"Binding Constants: The Measurement of Molecular Complex Stability","author":"Connors K. A.","year":"1987"},{"key":"e_1_2_8_65_1","unstructured":"R Core Team 2015 R: A Language and Environment for Statistical Computing R Foundation for Statistical Computing Vienna Austria https:\/\/www.R\u2010project.org(accessed: March 2025)."},{"key":"e_1_2_8_66_1","unstructured":"Studio Team 2015 RStudio: Integrated Development for R version 0.99.892 RStudio Inc. Boston MA https:\/\/www.rstudio.com (accessed: March 2025)."},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c00837"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3sc02586a"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b10302"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.4c00355"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct100641a"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1039\/F19827800437"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/585920"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1316"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.7b01729"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac3014498"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.3346"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13169"},{"key":"e_1_2_8_79_1","unstructured":"Spartan \u203224 version v.1.2.0 2024 Wavefunction Inc Irvine CA."},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b01176"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202523575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202523575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202523575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:01:35Z","timestamp":1789574495000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202523575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,17]]},"references-count":80,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,2,23]]}},"alternative-id":["10.1002\/anie.202523575"],"URL":"https:\/\/doi.org\/10.1002\/anie.202523575","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,17]]},"assertion":[{"value":"2025-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e23575"}}