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Herein, an axial sulfur\u2010bridged Mo\u2500S\u2500Cu nanozymes with asymmetric LEF (A\u2010CuN\n                    <jats:sub>3<\/jats:sub>\n                    S\n                    <jats:sub>1<\/jats:sub>\n                    @MoS\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    ) was constructed based on nanoislands (NIs)\u2010based axial ligand\u2010bridging to enhance ferroptosis\u2010pyroptosis therapy. The S bridge between Cu atoms in CuN\n                    <jats:sub>3<\/jats:sub>\n                    \/C nanosheets and Mo site in NIs creates a broad and enhanced LEF, which facilitates rapid electron transfer between the nanozyme and substrates, thereby regulating its enzymatic activities. Theoretical calculations reveal that the S\u2010bridge induces asymmetric electron\u2010rich redistribution along the longitudinal axis of Cu\u2500N\n                    <jats:sub>3<\/jats:sub>\n                    , promoting H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    heterolysis and O\n                    <jats:sub>2<\/jats:sub>\n                    desorption to enhance catalase\u2010like and peroxidase\u2010like activities. Simultaneously, Mo sites extract electrons from Cu via the S bridge, augmenting oxidase\u2010like activities and degrade overexpressed glutathione to avoid nontherapeutic ROS consumption. Consequently, A\u2010CuN\n                    <jats:sub>3<\/jats:sub>\n                    S\n                    <jats:sub>1<\/jats:sub>\n                    @MoS\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    induces robust ferroptosis by cytotoxic ROS accumulation and causing severe mitochondria damages, while simultaneously activating pyroptosis within the tumor region without harming normal tissues. This work demonstrates high\u2010efficiency ferroptosis\u2010pyroptosis therapy driven by multi\u2010enzyme catalysis via axial Mo\u2500S\u2500Cu coordination with an expanded asymmetric LEF, offering a novel strategy for non\u2010apoptotic tumor treatment.\n                  <\/jats:p>","DOI":"10.1002\/anie.202523888","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:22:31Z","timestamp":1774329751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Axial Sulfur\u2010Bridged Mo\u2010S\u2010Cu Nanozymes With an Asymmetric Local Electric Field Boosting Multi\u2010Enzymatic Activities for Ferroptosis\u2010Pyroptosis Therapy"],"prefix":"10.1002","volume":"65","author":[{"given":"Xiaoni","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Radiopharmaceuticals College of Chemistry Beijing Normal University  Beijing P.R. 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