{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:10:20Z","timestamp":1790183420225,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,3,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The conversion of CO\n                    <jats:sub>2<\/jats:sub>\n                    into energy\u2010dense liquid fuels, such as methanol, represents a cornerstone of sustainable chemistry; however, most homogeneous catalytic systems still rely on noble metals or Lewis acid additives. Here, we report the first protocol for amine\u2010assisted CO\n                    <jats:sub>2<\/jats:sub>\n                    hydrogenation to methanol using a Mn\u2013MACHO catalyst without any Lewis acid co\u2010catalyst, achieving turnover numbers up to 45.2, the highest reported for Mn systems. A combined computational, microkinetic, and experimental study reveals that diamines dramatically enhance activity compared to monoamines by promoting a highly exergonic double amidation step. This thermodynamic driving force shifts the equilibrium away from formate resting states toward the active catalyst, thereby accelerating methanol formation. The correlation established between amidation free energies (\u0394\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>amidation<\/jats:sub>\n                    ) and methanol productivity provides a rational design principle for tailoring amine promoters across Ru\u2010 and Mn\u2010based MACHO catalysts. These insights advance the development of sustainable, base\u2010metal\u2010catalyzed CO\n                    <jats:sub>2<\/jats:sub>\n                    conversion strategies and open opportunities for integrated carbon capture and utilization.\n                  <\/jats:p>","DOI":"10.1002\/anie.202524012","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:13:27Z","timestamp":1769519607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Leveraging Diamines to Unlock the Mn\u2010MACHO Catalyst in the Reduction of CO\n                    <sub>2<\/sub>\n                    to Methanol"],"prefix":"10.1002","volume":"65","author":[{"given":"Mohamed E. A.","family":"Safy","sequence":"first","affiliation":[{"name":"Hylleraas Centre for Quantum Molecular Sciences Department of Chemistry University of Oslo  Oslo 0315 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel J.","family":"Rama","sequence":"additional","affiliation":[{"name":"Center for Materials Science and Nanotechnology (SMN) Department of Chemistry University of Oslo  Oslo 0315 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas F.","family":"Both","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut f\u00fcr Katalyse e.V. Albert\u2010Einstein\u2010Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Balcells","sequence":"additional","affiliation":[{"name":"Hylleraas Centre for Quantum Molecular Sciences Department of Chemistry University of Oslo  Oslo 0315 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Junge","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut f\u00fcr Katalyse e.V. Albert\u2010Einstein\u2010Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Beller","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut f\u00fcr Katalyse e.V. Albert\u2010Einstein\u2010Stra\u00dfe 29a 18059 Rostock Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-7702","authenticated-orcid":false,"given":"Ainara","family":"Nova","sequence":"additional","affiliation":[{"name":"Hylleraas Centre for Quantum Molecular Sciences Department of Chemistry University of Oslo  Oslo 0315 Norway"},{"name":"Center for Materials Science and Nanotechnology (SMN) Department of Chemistry University of Oslo  Oslo 0315 Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"e_1_2_5_1_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00551"},{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja202642y"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5CS00186B"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01331E"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202207278"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00412"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS01331E"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.4c02513"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.organomet.4c00437"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.3c02412"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05302"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c05019"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcat.2022.112729"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja511329m"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b12763"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202500883"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202100649"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c04806"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b02066"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.7b03834"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fenrg.2023.1158499"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c05562"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.7b02931"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202524012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202524012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202524012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:56:29Z","timestamp":1790182589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202524012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,27]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,3,2]]}},"alternative-id":["10.1002\/anie.202524012"],"URL":"https:\/\/doi.org\/10.1002\/anie.202524012","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,27]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e24012"}}