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However, controlling intermediates dimerization remains highly challenging due to both the complexity of the catalytic systems and the limited mechanistic knowledge into the C\u2500C coupling process. In this work, a model dual\u2010site catalyst with precisely configured Fe\u2010O\u2010Cu sites is designed by covalently grafting iron\u2010phthalocyanine (FePc) onto copper nanowires via oxygen bridges (FeN\n                    <jats:sub>4<\/jats:sub>\n                    \u2010O\u2010Cu NW), which enables probing of atomic\u2010level mechanistic insights into the C\u2500C coupling pathways during electrochemical CO\n                    <jats:sub>2<\/jats:sub>\n                    reduction reaction (CO\n                    <jats:sub>2<\/jats:sub>\n                    RR). Remarkably, the FeN\n                    <jats:sub>4<\/jats:sub>\n                    \u2010O\u2010Cu NW exhibits a 23.6\u2010fold enhancement in the ethanol\u2010to\u2010ethylene Faradaic efficiency ratio as compared to O\u2010Cu NW, achieving\u00a0&gt;\u00a080% C\n                    <jats:sub>2+<\/jats:sub>\n                    Faradaic efficiency at an industrially relevant current density of 1\u00a0A cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    .\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    \/\n                    <jats:sup>12<\/jats:sup>\n                    CO co\u2010feed experiments together with a collection of\n                    <jats:italic>operando<\/jats:italic>\n                    \/in\u2010situ characterizations reveal that the enhanced ethanol selectivity over FeN\n                    <jats:sub>4<\/jats:sub>\n                    \u2010O\u2010Cu NW arises from asymmetric C\u2500C coupling between *CO and *CHO intermediates, where *CO is generated at the low\u2010spin single\u2010Fe\u2010atom site, while *CHO is produced at the oxygen\u2010bridged Cu site. Density functional theory (DFT) calculations further unveil that the oxygen\u2010bridged Fe\u2010O\u2010Cu site can not only stabilize the in situ generated low\u2010spin Fe(II) active site for enhancing CO\n                    <jats:sub>2<\/jats:sub>\n                    activation and lowering *CO desorption energy but also construct an oxygen\u2010bridged Cu active site to stabilize the *OCHO intermediate, significantly lowering the *OCHO\u2010to\u2010*CHO conversion energy barrier, orchestrating an efficient asymmetric *CO\u2500*CHO coupling path and boosting the CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010to\u2010ethanol conversion.\n                  <\/jats:p>","DOI":"10.1002\/anie.202524425","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T09:45:26Z","timestamp":1767951926000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Oxygen\u2010Bridged Dual Catalytic Sites Enable Asymmetric C\u2500C Coupling for Efficient CO\n                    <sub>2<\/sub>\n                    Electroreduction to Ethanol"],"prefix":"10.1002","volume":"65","author":[{"given":"Shifu","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics Chinese Academy of Sciences  Dalian 116023 China"},{"name":"Department of Chemical Physics University of Science and Technology of China  Hefei 230026 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering 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