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Traditional methods often rely on electrophilic aromatic substitution or transition metal catalysis with directing group strategies, which can result in product mixtures or require pre\u2010installed functional groups. In this respect, recent advances using single\u2010atom catalysts (SACs) are promising due to their enhanced reactivity and selectivity. This study introduces a robust catalytic system for undirected\n                    <jats:italic>para<\/jats:italic>\n                    \u2010C\u2500H functionalization of electron\u2010rich arenes by using an atomically dispersed copper\u2010based photocatalyst. The method bypasses the requirement of pre\u2010installed directing groups, achieving site\u2010selective functionalization through an\n                    <jats:italic>\u03b7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    interaction with arenes under mild conditions, with a broad substrate scope, and excellent catalyst recyclability. Furthermore, this approach offers a novel method for incorporating functional groups into complex drug molecules, which is crucial in the synthesis of pharmaceuticals and natural products.\n                  <\/jats:p>","DOI":"10.1002\/anie.202524517","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T06:46:31Z","timestamp":1777531591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Selective\n                    <i>Para<\/i>\n                    \u2010Functionalization of Aromatic C(sp\n                    <sup>2<\/sup>\n                    )\u2500H Bonds via Atomically Dispersed Photocatalysis"],"prefix":"10.1002","volume":"65","author":[{"given":"Jun","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Bayreuth  Bayreuth 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