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Here, we report an unprecedented three\u2010component 1,4\u2010amino oxygenation of 1,3\u2010dienes, enabled by copper catalysis and strong Br\u00f8nsted acid. The reaction engages a novel mechanism that merges umpolung electrophilic amination via copper(I)\u2010catalyzed formation of aminium radical cations and copper (II)\u2010mediated carbon\u2010oxygen bond formation\u00a0with alcohols. The observed 1,4\u2010selectivity is modulated by noncovalent interactions of aminated allylic intermediates. This method presents broad synthetic utility and offers a rapid entry to (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20101,4\u2010allylic amino ethers, which can be derivatized into various polyfunctional molecules with high stereocontrol.\n                  <\/jats:p>","DOI":"10.1002\/anie.202524557","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T06:30:38Z","timestamp":1766817038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Copper\u2010Catalyzed Three\u2010Component Selective 1,4\u2010Amino Oxygenation of 1,3\u2010Dienes"],"prefix":"10.1002","volume":"65","author":[{"given":"Guangshou","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Chemistry Duke University  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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