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Herein, we report that engineering Lewis acid sites in a mesoporous zeolite can greatly boost productivity. Incorporating a few of Sn species into KIT\u20106 zeolite with the assistance of phosphorylation delivered SnPO\/KIT(x) materials with abundant Lewis acid sites and a few of Br\u00f8nsted acid sites, while conserving the ordered mesoporous structure. Moreover, the Lewis acidic Sn sites have a coordination environment distinct from those in traditional zeolites and metal phosphates, as is crucial to facilitate isomerization and to control side\u2010reactions. Rigorous experiments showed that the use of SnPO\/KIT(80) catalyst in two\u2010step isomerization process combined with adequate hydrolysis of ethyl fructoside attains a fructose yield of 71.5%, surpassing the state\u2010of\u2010the\u2010art catalytic systems, along with good reusability and tolerance to high\u2010concentration glucose. These findings highlight the great potential of precisely manipulating coordination environment of Lewis acid sites to boost catalytic performance.<\/jats:p>","DOI":"10.1002\/anie.202524977","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T05:00:46Z","timestamp":1775451646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Engineering of Lewis Acid Sites in Mesoporous Zeolite Achieves Record Fructose Yield of 71.5% for Glucose Isomerization in Ethanol"],"prefix":"10.1002","volume":"65","author":[{"given":"Guanjie","family":"Yu","sequence":"first","affiliation":[{"name":"National &amp; Local Joint Engineering Research Center of Biomass Resource Utilization, College of Environmental Science and Engineering Nankai University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zejun","family":"Liu","sequence":"additional","affiliation":[{"name":"National 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