{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:09:17Z","timestamp":1790802557844,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A chemical reaction network (CRN) can generate complex molecules from simple starting materials through multiple interconnected reactions. The formose reaction, which produces monosaccharides from formaldehyde (HCHO), is a prototypical non\u2010enzymatic CRN. Although more than half of the feedstock in this reaction is converted into non\u2010target products (products other than the target monosaccharides), traditionally referred to as \u201ctar,\u201d the compositional evolution of these products has remained unexplored. In this study, we visualized the formose reaction's compositional landscape (target and non\u2010target products) by applying van Krevelen (VK) diagrams and Kendrick mass defect (KMD) plots using data from high\u2010resolution mass spectrometry, enabling comprehensive visualization of the products' composition without structural identification of individual compounds. Under NaOH catalysis, various side reactions proceeded with low selectivity, leading to a wide variety of non\u2010target products, whereas under Ca(OH)\n                    <jats:sub>2<\/jats:sub>\n                    catalysis, dehydration\u2010type side reactions became predominant in the later stages. These findings reveal that the product distribution in the formose reaction is highly catalyst\u2010 and stage\u2010dependent. The developed visualization framework provides a powerful tool for understanding complex CRNs and suggests rational strategies for reaction control, such as suppressing dehydration to improve the yield of target products in the presence of Ca(OH)\n                    <jats:sub>2<\/jats:sub>\n                    catalyst.\n                  <\/jats:p>","DOI":"10.1002\/anie.202525258","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T09:52:38Z","timestamp":1766829158000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network"],"prefix":"10.1002","volume":"65","author":[{"given":"Hiroaki","family":"Nishijima","sequence":"first","affiliation":[{"name":"Research Center for Solar Energy Chemistry Graduate School of Engineering Science The University of Osaka  1\u20133 Machikaneyama Toyonaka 560\u20138531 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiro","family":"Tabata","sequence":"additional","affiliation":[{"name":"Research Center for Solar Energy Chemistry Graduate School of Engineering Science The University of Osaka  1\u20133 Machikaneyama Toyonaka 560\u20138531 Japan"},{"name":"Presidential Endowed Chair for \u201cPlatinum Society\u201d The University of Tokyo  7\u20103\u20101 Hongo Bunkyo\u2010ku Tokyo 113\u20138656 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Hase","sequence":"additional","affiliation":[{"name":"Toyota Central R&amp;D Labs. 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