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Here, we report a strategic approach by engineering dynamic proton \u201chubs\u201d within hydrogen\u2010bonded organic frameworks (HOFs). These hubs are supramolecular secondary building units (SSBUs) formed by charge\u2010assisted hydrogen bonds between ammonium and sulfonate groups, which are programmed into the frameworks to direct proton traffic. The resulting ammonium\u2010sulfonate HOF,\n                    <jats:bold>\n                      BPDS_NH\n                      <jats:sub>4<\/jats:sub>\n                    <\/jats:bold>\n                    , exhibits a highly competitive proton conductivity of 0.21 S cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    (90\u00b0C, 90% RH). The exceptional performance is governed by the dual function of the proton hubs: their high charge density and hydrophilicity create a highway for vehicular transport of solvated proton clusters (H\n                    <jats:sup>+<\/jats:sup>\n                    (H\n                    <jats:sub>2<\/jats:sub>\n                    O)\n                    <jats:sub>n<\/jats:sub>\n                    ), while the dense, dynamic H\u2010bonded network within each hub serves as a confined arena for ultrafast Grotthuss hopping. These processes are synergistically coupled, as verified by activation energy analysis and H\/D isotope effect. This work establishes the construction of supramolecular proton hubs as a versatile blueprint for the rational design of advanced proton\u2010conducting materials.\n                  <\/jats:p>","DOI":"10.1002\/anie.202525282","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:43:30Z","timestamp":1772977410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Engineering Dynamic Proton \u201cHubs\u201d in Hydrogen\u2010Bonded Frameworks for Superprotonic Conductivity"],"prefix":"10.1002","volume":"65","author":[{"given":"Yilin","family":"Luo","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Advanced Nuclear Energy Technology Institute of Nuclear and New Energy Technology Tsinghua University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Su","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Advanced Nuclear Energy Technology Institute of Nuclear and New Energy Technology Tsinghua University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Nuclear Science and Technology Lanzhou University  Lanzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xie","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Advanced Nuclear Energy Technology Institute of Nuclear and New Energy Technology Tsinghua University  Beijing P.R. 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