{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:42:38Z","timestamp":1791337358050,"version":"4.3.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22225808"],"award-info":[{"award-number":["22225808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20551"],"award-info":[{"award-number":["U24A20551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22476101"],"award-info":[{"award-number":["22476101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22275196"],"award-info":[{"award-number":["22275196"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22106078"],"award-info":[{"award-number":["22106078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFA1206200"],"award-info":[{"award-number":["2022YFA1206200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,3,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hydrogen\u2010bonded water clusters (H\n                    <jats:sub>2<\/jats:sub>\n                    O)\n                    <jats:sub>n<\/jats:sub>\n                    obscure the intrinsic reactivity of monomeric H\n                    <jats:sub>2<\/jats:sub>\n                    O (n = 1) by restricting molecular reorientation. Elucidating the catalytic behavior of isolated water remains a key challenge in aqueous\u2010phase chemistry. Here, we address this by designing a molecular crystal that uniformly confines single water molecules in identical tetrahedral cavities. This platform,\n                    <jats:bold>\n                      CB\u2010H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                    <\/jats:bold>\n                    , exhibits exceptional activity for photocatalytic H\n                    <jats:sub>2<\/jats:sub>\n                    O\u2010to\u2010H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    conversion, achieving 7.03\u00a0mmol g\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    h\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    with pure water, representing an 11.6\u2010fold enhancement over cavity\u2010deficient controls and being markedly superior to existing photocatalytic systems. This performance advantage is directly attributed to the crystallographically defined monomeric water, as verified by isotopic labelling and in\u2010situ spectroscopy. Theoretical calculations further demonstrate that cavity confinement eliminates hydrogen\u2010bond reorganization penalties, substantially lowering the activation barrier for water oxidation. Our work establishes monomeric\u2010water catalysis as a distinct and efficient paradigm, showcasing molecular crystal engineering as a versatile approach to tailoring water\u2010involved reactions for sustainable catalysis.\n                  <\/jats:p>","DOI":"10.1002\/anie.202525362","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T10:53:14Z","timestamp":1770029594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Confining a Single Water Molecule Through Molecular Crystal Engineering for Water Oxidation"],"prefix":"10.1002","volume":"65","author":[{"given":"Long","family":"Pan","sequence":"first","affiliation":[{"name":"School of Chemistry &amp; Chemical Engineering\/School of Materials Science &amp; Engineering Jiangsu University  Zhenjiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; Chemical Engineering\/School of Materials Science &amp; Engineering Jiangsu University  Zhenjiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengwei","family":"Huo","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; Chemical Engineering\/School of Materials Science &amp; Engineering Jiangsu University  Zhenjiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Environment and Health Inner Mongolia Normal University  Hohhot P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; Chemical Engineering\/School of Materials Science &amp; Engineering Jiangsu University  Zhenjiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1298-5436","authenticated-orcid":false,"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemistry CAS Research\/Education Center For Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-9691","authenticated-orcid":false,"given":"Yongxian","family":"Guo","sequence":"additional","affiliation":[{"name":"Qilu University of Technology (Shandong Academy of Sciences) Shandong Analysis and Test Center  Jinan P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2393-3017","authenticated-orcid":false,"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Chemistry &amp; Chemical Engineering\/School of Materials Science &amp; Engineering Jiangsu University  Zhenjiang P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb9385"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201049404\u20109"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929-022-00843-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.ads4369"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57403-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44221-023-00139-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar500314j"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09176-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b02264"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42004-020-00396-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-28783-x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c02237"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201014251\u20106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC07339B"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33696-w"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-024-01546-5"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2545"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010018\u20100141\u20105"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202006013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2212497119"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5EE02150B"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201412035"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp036735i"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c01702"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31981"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44753-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0107348"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701482104"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000601117"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2852(79)90019-5"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202525362","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202525362","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202525362","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:43:45Z","timestamp":1773067425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202525362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,1]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,3,9]]}},"alternative-id":["10.1002\/anie.202525362"],"URL":"https:\/\/doi.org\/10.1002\/anie.202525362","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,1]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e25362"}}