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Supramolecular assemblies have recently emerged as promising biofilm\u2010eradicating agents with enhanced surface adhesion. Yet, supramolecular polymers, although endowed with comparable or even greater potential, remain largely untapped in this arena. Herein, we introduce NOP@CB[8], a flower\u2010like supramolecular polymer self\u2010assembled in water from a\n                    <jats:italic>de novo<\/jats:italic>\n                    designed cationic pyridinium salt (NOP) and cucurbit[8]uril (CB[8]). Acting as a multifunctional agent, NOP@CB[8] disrupts bacterial membranes, perturbs redox equilibrium, disintegrates biofilms, and concurrently enhances foliar affinity. These combined attributes endow NOP@CB[8] with potent in vivo efficacy, exhibiting protective and curative efficacies of 56.1% and 51.2%, respectively, at 200\u00a0\n                    <jats:italic>\u00b5g<\/jats:italic>\n                    mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    against rice bacterial leaf blight, thereby surpassing both free NOP (47.9%\/43.1%) and thiodiazole copper (TC, 36.2%\/33.7%). Remarkably, NOP@CB[8] delivers high control efficacy with uncompromised safety toward both target and non\u2011target organisms, even demonstrates enhanced safety in zebrafish relative to free NOP. Extending its scope to citrus and kiwifruit cankers, NOP@CB[8] achieves approximately 80% protective and over 60% curative efficacy, consistently outperforming NOP and TC. Together, this study delineates a green alternative for crop protection and a conceptual framework for next\u2010generation functional supramolecular polymers.\n                  <\/jats:p>","DOI":"10.1002\/anie.202525538","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:40:22Z","timestamp":1773013222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Flower\u2010Shaped Supramolecular Polymer Enabling Biofilm Eradication, Improved Foliar Affinity, and Bacterial Disease Management"],"prefix":"10.1002","volume":"65","author":[{"given":"Xiaoxue","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center For Research and Development of Fine Chemicals of Guizhou University  Guiyang 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