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To address the challenge of co\u2010converting methane (CH\n                    <jats:sub>4<\/jats:sub>\n                    ) and carbon dioxide (CO\n                    <jats:sub>2<\/jats:sub>\n                    ), we developed a solar\u2010driven biohybrid system that synergistically integrates biosynthesis and photocatalysis. The core of this system relies on a genetically engineered methanotrophic cell factory and newly designed biocompatible photocatalytic metal complexes. The methanotrophic bacteria utilize CH\n                    <jats:sub>4<\/jats:sub>\n                    as the primary feedstock to biosynthesize 4\u2010hydroxybenzoate (4HBA) while realizing CO\n                    <jats:sub>2<\/jats:sub>\n                    sequestration. The photocatalytic metal complexes, meanwhile, capture formate (a metabolic byproduct of cells) to generate hydrogen (H\n                    <jats:sub>2<\/jats:sub>\n                    ) and photoelectrons\u2014with the latter directly supplying reducing power to support cellular activities in genetically tailored cells. Under optimal conditions, this solar\u2010driven system achieved a 4HBA titer of 472.36\u00a0\u00b5g\/L, a H\n                    <jats:sub>2<\/jats:sub>\n                    yield of 0.59\u00a0mmol H\n                    <jats:sub>2<\/jats:sub>\n                    \/mol CH\n                    <jats:sub>4<\/jats:sub>\n                    , and over 50% reduction in carbon emissions. The study not only establishes a feasible biomanufacturing strategy for the upcycling of C\n                    <jats:sub>1<\/jats:sub>\n                    gaseous feedstocks but also highlights the potential of integrating biological and photochemical technologies to advance sustainable energy and environmental solutions.\n                  <\/jats:p>","DOI":"10.1002\/anie.202526097","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:56:13Z","timestamp":1773989773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bio\u2010Photocatalytic Synergy Enables Valorization of CH\n                    <sub>4<\/sub>\n                    and CO\n                    <sub>2<\/sub>\n                    Into Hydrogen and 4\u2010Hydroxybenzoate in Engineered Methanotrophic Bacteria"],"prefix":"10.1002","volume":"65","author":[{"given":"Ziyue","family":"Jiao","sequence":"first","affiliation":[{"name":"Xi'an Key Laboratory of C1 Compound Bioconversion Technology Xi'an Jiaotong University  Xi'an P. 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