{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:16:15Z","timestamp":1775538975915,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC25SC26"],"award-info":[{"award-number":["NSFC25SC26"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,4,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chagas disease is classified as a neglected tropical disease (NTD) and is predominantly endemic in South America. Despite advances in modern medicine, more than 10 million people worldwide are currently infected, and approximately 12\u00a0000 deaths are reported annually. The World Health Organization (WHO) aims to eliminate Chagas disease by 2030. Although more than 100 years have passed since the discovery of Chagas disease, no effective vaccine has yet been developed. The only available chemotherapeutic agents are nifurtimox and benznidazole, both of which were introduced more than half a century ago and are included in the WHO's list of essential medicines. However, because these drugs are associated with severe adverse effects and are effective only during the early phase of infection, they have not achieved eradication of Chagas disease. In this study, a scalable synthetic method was developed for noncanonical cyclic peptides bearing a rare\n                    <jats:italic>N<\/jats:italic>\n                    \u2010acylindole linkage, a structural motif not typically observed in conventional cyclic peptides. This strategy enabled the synthesis of bulbiferamide A, a potent antitrypanosomal agent reported to be effective against Chagas disease, as well as a variety of related analogues that had previously been difficult to access synthetically.\n                  <\/jats:p>","DOI":"10.1002\/anie.202526149","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:27:36Z","timestamp":1773005256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scalable Access to\n                    <i>N<\/i>\n                    \u2011Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease"],"prefix":"10.1002","volume":"65","author":[{"given":"Jie","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Chemistry The Hong Kong University of Science and Technology (HKUST)  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5475-7883","authenticated-orcid":false,"given":"Hugh","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Chemistry The Hong Kong University of Science and Technology (HKUST)  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074\u201002760200372"},{"key":"e_1_2_7_3_1","unstructured":"WHO.World Chagas Disease Day https:\/\/www.who.int\/campaigns\/world\u2010chagas\u2010disease\u2010day(accessed Aug 18 2023)."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003259"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(10)60061\u2010X"},{"key":"e_1_2_7_6_1","unstructured":"Chagas Disease in Latin America: An epidemiological update based on 2010 estimates. Weekly Epidemiological Record(World Health Organization 2015)."},{"key":"e_1_2_7_7_1","unstructured":"Integrating Neglected Tropical Diseases Into Global Health and Development: Fourth WHO Report on Neglected Tropical Diseases (World Health Organization 2017). Licence: CC BY\u2010NC\u2010SA 3.0 IGO."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5334\/gh.484"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.105080"},{"key":"e_1_2_7_10_1","unstructured":"WHO.Chagas disease (also known as American trypanosomiasis) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/chagas\u2010disease\u2010(american\u2010trypanosomiasis)."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01787\u20107"},{"key":"e_1_2_7_12_1","volume-title":"Pan American Health Organization. Guidelines for the Diagnosis and Treatment of Chagas Disease","year":"2019"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2024.103084"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(96)04128\u20101"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007668"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074\u201002762009000400002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112020"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v32i2.458"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz473"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw477"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ230"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0013218"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01135\u201020"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.05.019"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008912"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(01)00065\u20102"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202100432"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.2c01083"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202300190"},{"key":"e_1_2_7_31_1","volume-title":"Dictionary of Natural Products","year":"1993"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0303714"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0497954"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2005.16"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo0264980"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2014.07.113"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM\u201016\u201013465"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.2c01228"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3987\/R\u20101982\u201001\u20100091"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201203976"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b02097"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.18.9"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cctc.202201596"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.202300487"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol900306v"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajoc.202500542"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC08672E"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.4c03648"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4SC07839J"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.33"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c01561"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v29i3.15"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed10020050"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo4282"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b01369"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja907193b"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b09067"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05892"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c05891"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.22377\/ijpba.v15i02.2127"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.aihch.2015.04.003"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.202500121"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c11016"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202409987"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202516053"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202400637"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tchem.2024.100084"}],"container-title":["Angewandte Chemie International Edition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202526149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/anie.202526149","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/anie.202526149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:36:52Z","timestamp":1775536612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202526149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":66,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,4,6]]}},"alternative-id":["10.1002\/anie.202526149"],"URL":"https:\/\/doi.org\/10.1002\/anie.202526149","archive":["Portico"],"relation":{},"ISSN":["1433-7851","1521-3773"],"issn-type":[{"value":"1433-7851","type":"print"},{"value":"1521-3773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e26149"}}