{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:44:58Z","timestamp":1792079098393,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"36","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22171251"],"award-info":[{"award-number":["22171251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024MB122"],"award-info":[{"award-number":["ZR2024MB122"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Angew Chem Int Ed"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polycyclic cembrane diterpenoids and norditerpenoids have garnered sustained interest from the synthetic community due to their unique polycyclic frameworks and promising biological activities. Herein, we report a 13\u2010step total synthesis of (+)\u2010ineleganolide, a highly oxidized cembrane norditerpenoid possessing a synthetically challenging [6,7,5,5,5] cage\u2010type pentacyclic scaffold. This synthesis is highlighted by a novel strategy relying on an intramolecular Diels\u2013Alder reaction that stereoselectively constructs the pivotal [6,6,5,5,5] pentacyclic framework as a single diastereoisomer, addressing stereochemical control challenges. In the late\u2010stage elaboration, a tandem epoxidation\/Meinwald rearrangement efficiently forges the sterically congested central seven\u2010membered ring. This synthetic strategy provides a new blueprint for accessing other members of the cembrane norditerpenoid family.<\/jats:p>","DOI":"10.1002\/anie.2110292","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:25:26Z","timestamp":1783931126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetric Total Synthesis of (+)\u2010Ineleganolide"],"prefix":"10.1002","volume":"65","author":[{"given":"Changhong","family":"Han","sequence":"first","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Tian","sequence":"additional","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Ding","sequence":"additional","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Pan","sequence":"additional","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-1679","authenticated-orcid":false,"given":"Weiwu","family":"Ren","sequence":"additional","affiliation":[{"name":"Molecular Synthesis Center &amp; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy Ocean University of China  Qingdao China"},{"name":"Laboratory For Marine Drugs and Bioproducts Qingdao Marine Science and Technology Center  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00083"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1np00023c"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00405a009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07388"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201900782"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c02513"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12401"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02317"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.09.040"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09583"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c03995"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c08245"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202315481"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja076172e"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5b02550"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6SC03347D"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b02030"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.7b02825"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.9b00635"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2021.132289"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c09826"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02142"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c09467"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c16629"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c17640"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(99)01194\u20106"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12074045"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00988"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103350"},{"key":"e_1_2_5_31_1","unstructured":"During the manuscript preparation of our work Maimone's group published their work on total synthesis of (+)\u2010ineleganolide."},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja100041e"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521\u20103773(20020517)41:10<1668::AID\u2010ANIE1668>3.0.CO;2\u2010Z"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1338426"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001295\u2010x"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja501782r"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo300046v"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0262340"},{"key":"e_1_2_5_39_1","unstructured":"Deposition number 2514145 (for28) contain the supplementary crystallographic data for this paper. 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