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In this context, the analysis of carbon residual chemical shift anisotropies (\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010RCSAs) and residual dipolar couplings (RDCs) was essential for distinguishing the relative configurations of two tetraprenyltoluquinol epimeric meroterpenoids at C3 (\n                    <jats:bold>1a<\/jats:bold>\n                    and\n                    <jats:bold>1b<\/jats:bold>\n                    ). These compounds feature two remotely located stereoclusters and exhibit significant conformational flexibility. DP4\u2010based approaches (DP4+ or\n                    <jats:italic>J<\/jats:italic>\n                    \u2010DP4) failed to differentiate these epimers. A geometric exploration strategy was developed to investigate the conformational diversity of\n                    <jats:bold>1a<\/jats:bold>\n                    and\n                    <jats:bold>1b<\/jats:bold>\n                    while accounting for their inherent flexibility. Then, refining the conformational space and optimizing the fitting of the anisotropic parameters of\n                    <jats:bold>1a<\/jats:bold>\n                    \/\n                    <jats:bold>1b<\/jats:bold>\n                    measured in a 3\u00a0mm semi\u2010micro compression device using poly\u2010HEMA gels in DMSO enabled us to discriminate the relative configuration of them.\n                  <\/jats:p>","DOI":"10.1002\/anie.2111490","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:17:17Z","timestamp":1779704237000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility"],"prefix":"10.1002","volume":"65","author":[{"given":"Juan Carlos C.","family":"Fuentes\u2010Monteverde","sequence":"first","affiliation":[{"name":"NMR Based Structural Biology MPI for Multidisciplinary Sciences  G\u00f6ttingen Germany"},{"name":"Facultade de Ciencias CICA\u2010Centro Interdisciplinar de Qu\u00edmica e Biolox\u00eda e Departamento de Qu\u00edmica Universidade Da Coru\u00f1a A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel M.","family":"Forero","sequence":"additional","affiliation":[{"name":"Facultade de Ciencias CICA\u2010Centro Interdisciplinar de Qu\u00edmica e Biolox\u00eda e Departamento de Qu\u00edmica Universidade Da Coru\u00f1a A Coru\u00f1a Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilamoni","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Chemistry Gauhati University  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Hern\u00e1ndez","family":"Daranas","sequence":"additional","affiliation":[{"name":"Instituto de Productos Naturales y Agrobiolog\u00eda, Consejo Superior de Investigaciones Cientificas 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